SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		3 / 3 VAL B  60
VAL B  94
TRP B  63
 None
 0.95A 1bdwA-4xxwB:
undetectable
1bdwB-4xxwB:
undetectable		 1bdwA-4xxwB:
8.16
1bdwB-4xxwB:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 6 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.37A 1dz4B-4xxwB:
undetectable		 1dz4B-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		4 / 5 PHE B 183
TYR B 207
LEU B 234
VAL B 141
 None
 1.42A 1dz6A-4xxwB:
undetectable		 1dz6A-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		4 / 5 PHE B 183
TYR B 207
VAL B 135
VAL B 141
 None
 1.41A 1dz6B-4xxwB:
undetectable		 1dz6B-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 9 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.38A 1dz8B-4xxwB:
undetectable		 1dz8B-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 9 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.39A 1dz9B-4xxwB:
undetectable		 1dz9B-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 9 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.38A 1iwjA-4xxwB:
undetectable		 1iwjA-4xxwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		4 / 7 TYR B 207
ASN B 200
HIS B 236
TYR B 201
 None
 1.34A 1mxgA-4xxwB:
undetectable		 1mxgA-4xxwB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 10 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.37A 1o76A-4xxwB:
undetectable		 1o76A-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 7 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.33A 1t85A-4xxwB:
undetectable		 1t85A-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 7 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.38A 1t87A-4xxwB:
undetectable		 1t87A-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 10 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.36A 2cp4A-4xxwB:
undetectable		 2cp4A-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 5 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.36A 2m56A-4xxwB:
undetectable		 2m56A-4xxwB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		4 / 5 ASP B  85
ASP B 159
ASP B 118
ARG B 119
 CA  B1002 ( 2.2A)
CA  B1002 ( 3.2A)
CA  B1002 (-3.2A)
None
 1.27A 3naiA-4xxwB:
undetectable		 3naiA-4xxwB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		4 / 5 ASP B 118
ASP B  85
ASP B 159
ARG B 224
 CA  B1002 (-3.2A)
CA  B1002 ( 2.2A)
CA  B1002 ( 3.2A)
None
 1.41A 3naiA-4xxwB:
undetectable		 3naiA-4xxwB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 6 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.35A 4g3rB-4xxwB:
undetectable		 4g3rB-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 6 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.31A 4kkyX-4xxwB:
undetectable		 4kkyX-4xxwB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 5 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.35A 4l49A-4xxwB:
undetectable		 4l49A-4xxwB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 6 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.32A 4l4cA-4xxwB:
undetectable		 4l4cA-4xxwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 7 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.32A 4l4gA-4xxwB:
undetectable		 4l4gA-4xxwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4xxw PROTOCADHERIN-15
(Mus
musculus) 		5 / 7 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.30A 5wk9A-4xxwB:
undetectable		 5wk9A-4xxwB:
19.10