SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		4 / 5 THR A  40
GLU A  38
THR A 142
HIS A 216
 None
 1.43A 1d4fA-4xy3A:
undetectable		 1d4fA-4xy3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		4 / 5 THR A  40
GLU A  38
THR A 142
HIS A 216
 None
 1.42A 1d4fB-4xy3A:
undetectable		 1d4fB-4xy3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		4 / 5 THR A  40
GLU A  38
THR A 142
HIS A 216
 None
 1.46A 1d4fD-4xy3A:
undetectable		 1d4fD-4xy3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 185
LEU A 188
ASP A 189
 None
 0.30A 3ko0A-4xy3A:
undetectable		 3ko0A-4xy3A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 185
LEU A 188
ASP A 189
 None
 0.29A 3ko0T-4xy3A:
undetectable		 3ko0T-4xy3A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 123
VAL A 122
GLN A  47
 None
 0.74A 3of4B-4xy3A:
undetectable		 3of4B-4xy3A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  41
ALA A 268
VAL A 212
LEU A 140
HIS A 216
 None
 1.19A 5eb5A-4xy3A:
undetectable		 5eb5A-4xy3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  41
ALA A 268
VAL A 212
LEU A 140
HIS A 216
 None
 1.20A 5eb5B-4xy3A:
undetectable		 5eb5B-4xy3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 121
PRO A 272
ASN A 274
 None
 0.96A 5jwaA-4xy3A:
undetectable
5jwaH-4xy3A:
undetectable		 5jwaA-4xy3A:
21.39
5jwaH-4xy3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		5 / 12 PRO A  28
LEU A  60
PHE A 159
GLY A 155
HIS A 151
 None
 1.00A 5l6eA-4xy3A:
undetectable		 5l6eA-4xy3A:
15.88