SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 9 LEU A 208
VAL A 207
ILE A 159
VAL A 251
ILE A 252
 None
 1.42A 1gebA-4xybA:
undetectable		 1gebA-4xybA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		4 / 8 ARG A 164
LEU A 160
VAL A 216
GLY A 192
 None
 0.91A 1hrkA-4xybA:
4.5		 1hrkA-4xybA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		4 / 8 ARG A 164
LEU A 160
VAL A 216
GLY A 192
 None
 0.94A 1hrkB-4xybA:
4.1		 1hrkB-4xybA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 GLU A 175
ASP A 182
ILE A 180
GLY A 177
ILE A 172
 None
 1.34A 1q8jA-4xybA:
undetectable		 1q8jA-4xybA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		3 / 3 SER A 335
GLY A 336
ARG A 285
 NDP  A 401 (-3.1A)
NDP  A 401 (-3.3A)
AZI  A 402 ( 2.9A)
 0.53A 1t9wA-4xybA:
undetectable		 1t9wA-4xybA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 THR A 120
GLY A 122
GLY A 336
ILE A  95
GLN A  97
 None
AZI  A 402 (-3.6A)
NDP  A 401 (-3.3A)
None
None
 1.22A 2akeA-4xybA:
undetectable		 2akeA-4xybA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 THR A 120
GLY A 122
GLY A 336
ILE A  95
GLN A  97
 None
AZI  A 402 (-3.6A)
NDP  A 401 (-3.3A)
None
None
 1.22A 2azxA-4xybA:
undetectable		 2azxA-4xybA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 THR A 120
GLY A 122
GLY A 336
ILE A  95
GLN A  97
 None
AZI  A 402 (-3.6A)
NDP  A 401 (-3.3A)
None
None
 1.24A 2azxB-4xybA:
undetectable		 2azxB-4xybA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 GLU A 175
ASP A 182
ILE A 180
GLY A 177
ILE A 172
 None
 1.25A 2e7fA-4xybA:
undetectable		 2e7fA-4xybA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 10 PHE A  99
GLY A 348
THR A 349
ALA A 346
ALA A 347
 AZI  A 402 ( 4.3A)
None
None
None
None
 0.89A 2ej3B-4xybA:
undetectable		 2ej3B-4xybA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 GLU A 175
ASP A 182
ILE A 180
GLY A 177
ILE A 172
 None
 1.24A 2ogyA-4xybA:
undetectable		 2ogyA-4xybA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 GLU A 175
ASP A 182
ILE A 180
GLY A 177
ILE A 172
 None
 1.32A 2ogyB-4xybA:
undetectable		 2ogyB-4xybA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 GLY A 341
GLY A 122
GLY A 336
THR A 120
ILE A  95
 None
AZI  A 402 (-3.6A)
NDP  A 401 (-3.3A)
None
None
 1.05A 2oxtA-4xybA:
5.3		 2oxtA-4xybA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		4 / 8 ARG A 164
LEU A 160
VAL A 216
GLY A 192
 None
 0.97A 2po5A-4xybA:
4.5		 2po5A-4xybA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		4 / 7 TYR A 382
TYR A 259
PRO A 260
THR A 262
 None
NDP  A 401 (-4.7A)
None
NDP  A 401 (-4.4A)
 1.03A 2q6kA-4xybA:
undetectable		 2q6kA-4xybA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 SER A  96
GLY A 124
GLY A 122
ILE A 368
VAL A 128
 None
NDP  A 401 ( 4.0A)
AZI  A 402 (-3.6A)
None
None
 1.26A 3fzgA-4xybA:
3.7		 3fzgA-4xybA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		4 / 7 GLU A 153
VAL A 156
ALA A 206
ARG A 210
 None
 0.96A 3kp6B-4xybA:
undetectable		 3kp6B-4xybA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 10 LEU A 208
GLY A 201
ASP A  33
GLY A 148
VAL A 151
 None
NDP  A 401 (-3.5A)
None
None
NDP  A 401 (-4.6A)
 0.97A 3oxwA-4xybA:
undetectable		 3oxwA-4xybA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		4 / 7 GLY A 348
THR A 349
ILE A 352
THR A 377
 None
 0.79A 4acaC-4xybA:
3.2		 4acaC-4xybA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		3 / 3 MET A 193
MET A 245
TYR A 279
 None
 1.43A 4p6xI-4xybA:
undetectable		 4p6xI-4xybA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 TYR A 345
ALA A 343
PHE A 145
HIS A 154
ILE A 123
 None
None
None
None
NDP  A 401 ( 3.6A)
 1.11A 4rvdA-4xybA:
6.5		 4rvdA-4xybA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 ALA A 121
LEU A  60
LEU A  58
LEU A  51
LEU A 119
 None
 1.18A 4zn7A-4xybA:
undetectable		 4zn7A-4xybA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		4 / 6 GLY A 341
SER A 146
TYR A 345
GLY A 148
 None
 0.73A 5k4pA-4xybA:
undetectable		 5k4pA-4xybA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		3 / 3 GLU A 365
ARG A 363
TYR A 366
 None
 0.63A 5trqB-4xybA:
undetectable		 5trqB-4xybA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		3 / 3 GLY A 378
THR A 283
PRO A 257
 None
None
NDP  A 401 (-3.5A)
 0.66A 5v5zA-4xybA:
undetectable		 5v5zA-4xybA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4xyb FORMATE
DEHYDROGENASE
(Granulicella
mallensis) 		5 / 12 ALA A 222
GLY A 204
GLY A 201
ARG A 209
VAL A 198
 NDP  A 401 (-3.4A)
None
NDP  A 401 (-3.5A)
None
None
 1.25A 6clxA-4xybA:
undetectable		 6clxA-4xybA:
23.88