SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		4 / 6 THR A 388
THR A 395
THR A 325
ILE A 321
 None
 0.92A 1gtnD-4xydA:
undetectable
1gtnE-4xydA:
undetectable		 1gtnD-4xydA:
10.67
1gtnE-4xydA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 TYR A 255
GLY A 260
GLU A 267
SER A 264
PHE A 248
 None
None
HEM  A 504 (-4.5A)
HEM  A 504 ( 4.1A)
None
 1.47A 1maaA-4xydA:
undetectable		 1maaA-4xydA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		4 / 8 GLY A 244
TYR A 247
GLU A 267
TYR A 191
 None
None
HEM  A 504 (-4.5A)
None
 1.10A 1maaD-4xydA:
undetectable		 1maaD-4xydA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans;
Roseobacter
denitrificans) 		5 / 11 GLU A 119
GLY A 120
LEU B 121
GLU B 125
HIS B  55
 None
 1.21A 1mjqA-4xydA:
undetectable
1mjqB-4xydA:
undetectable		 1mjqA-4xydA:
12.72
1mjqB-4xydA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		4 / 7 PHE A 141
ALA A  69
TYR A  12
ILE A  81
 None
 1.12A 1oniA-4xydA:
undetectable
1oniB-4xydA:
undetectable		 1oniA-4xydA:
14.88
1oniB-4xydA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		3 / 3 TRP A 129
VAL A 128
PRO A 127
 None
 0.99A 1rg1A-4xydA:
undetectable		 1rg1A-4xydA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		3 / 3 TRP A 129
VAL A 128
PRO A 127
 None
 0.99A 1rh0A-4xydA:
undetectable		 1rh0A-4xydA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		4 / 6 HIS A 194
PHE A 237
LEU A 236
ILE A 240
 FE  A 505 (-2.9A)
None
None
None
 1.22A 1sbrA-4xydA:
undetectable
1sbrB-4xydA:
undetectable		 1sbrA-4xydA:
16.48
1sbrB-4xydA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		4 / 5 PHE A 339
LEU A 348
MET A 380
LEU A  30
 HEM  A 504 ( 3.8A)
None
HEM  A 501 (-4.3A)
HEM  A 501 (-3.7A)
 1.23A 1skxA-4xydA:
1.6		 1skxA-4xydA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 10 GLY A 242
GLY A 244
GLU A 267
SER A 264
PHE A 248
 None
None
HEM  A 504 (-4.5A)
HEM  A 504 ( 4.1A)
None
 1.12A 1w76B-4xydA:
undetectable		 1w76B-4xydA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 LEU A 209
ALA A 305
LEU A 304
SER A 345
VAL A 344
 None
 1.20A 2c12C-4xydA:
3.7		 2c12C-4xydA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		4 / 8 GLY A 391
THR A 331
ALA A 332
ALA A 333
 None
HEM  A 504 (-2.7A)
HEM  A 501 ( 4.9A)
None
 0.54A 2ej3A-4xydA:
undetectable		 2ej3A-4xydA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		4 / 8 PHE A  39
PHE A  46
GLY A  26
GLY A  27
 None
None
None
HEM  A 501 (-3.5A)
 0.90A 2qx4A-4xydA:
undetectable
2qx4B-4xydA:
undetectable		 2qx4A-4xydA:
19.70
2qx4B-4xydA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 10 ILE A 157
PHE A 277
MET A 281
TYR A 353
VAL A 219
 None
 1.37A 2w98A-4xydA:
undetectable		 2w98A-4xydA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		3 / 3 SER A  36
THR A 413
PHE A 405
 None
 0.76A 2x91A-4xydA:
undetectable		 2x91A-4xydA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans) 		5 / 12 TYR A 416
PHE A 405
ILE A 412
ALA B  73
TYR A  34
 None
None
None
HEM  A 501 (-3.3A)
HEM  A 501 (-4.7A)
 1.37A 3apwA-4xydA:
undetectable		 3apwA-4xydA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 PHE A  13
GLN A  90
ASN A 144
VAL A 149
LEU A 162
 None
 1.25A 3em0B-4xydA:
undetectable		 3em0B-4xydA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 GLY A  26
VAL A  49
LEU A  57
MET A 376
ILE A  33
 None
None
HEM  A 501 (-3.6A)
None
None
 1.17A 3h52B-4xydA:
undetectable		 3h52B-4xydA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans) 		5 / 9 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.34A 3p4wA-4xydA:
1.7		 3p4wA-4xydA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		3 / 3 PHE A 248
SER A 264
SER A 261
 None
HEM  A 504 ( 4.1A)
None
 0.89A 3ufgB-4xydA:
undetectable		 3ufgB-4xydA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
 None
None
HEM  A 501 ( 4.5A)
None
None
 1.08A 4coxA-4xydA:
undetectable		 4coxA-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
 None
None
HEM  A 501 ( 4.5A)
None
None
 1.08A 4coxB-4xydA:
undetectable		 4coxB-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
 None
None
HEM  A 501 ( 4.5A)
None
None
 1.08A 4coxD-4xydA:
undetectable		 4coxD-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 11 TYR A 255
GLY A 260
GLU A 267
SER A 264
GLY A 239
 None
None
HEM  A 504 (-4.5A)
HEM  A 504 ( 4.1A)
None
 1.41A 4ey7A-4xydA:
undetectable		 4ey7A-4xydA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans;
Roseobacter
denitrificans) 		3 / 3 TYR A 416
PHE A 405
ARG B 114
 None
 1.16A 4g19D-4xydA:
undetectable		 4g19D-4xydA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		3 / 3 PRO A 127
TYR A 105
GLY A 100
 None
 0.74A 4g2zA-4xydA:
undetectable		 4g2zA-4xydA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans;
Roseobacter
denitrificans) 		4 / 7 GLU B  58
ASP A 185
ILE B  68
TRP B  57
 None
 1.18A 4ii8A-4xydB:
undetectable		 4ii8A-4xydB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 10 HIS A 396
TYR A 324
ARG A 399
HIS A 319
GLY A 320
 None
 1.34A 4lb9A-4xydA:
1.2		 4lb9A-4xydA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		4 / 6 GLY A  64
ILE A   8
ILE A 350
LEU A 161
 None
 0.76A 4o8fB-4xydA:
undetectable		 4o8fB-4xydA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
 None
None
HEM  A 501 ( 4.5A)
None
None
 1.02A 4otyA-4xydA:
undetectable		 4otyA-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
 None
None
HEM  A 501 ( 4.5A)
None
None
 1.02A 4otyB-4xydA:
undetectable		 4otyB-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
 None
None
HEM  A 501 ( 4.5A)
None
None
 0.95A 4rrwC-4xydA:
undetectable		 4rrwC-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
 None
None
HEM  A 501 ( 4.5A)
None
None
 0.98A 4rrwD-4xydA:
undetectable		 4rrwD-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
 None
None
HEM  A 501 ( 4.5A)
None
None
 0.95A 4rrzC-4xydA:
undetectable		 4rrzC-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
 None
None
HEM  A 501 ( 4.5A)
None
None
 0.98A 4rrzD-4xydA:
undetectable		 4rrzD-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4xyd NORC-LIKE PROTEIN
(Roseobacter
denitrificans) 		3 / 3 THR B  45
THR B  47
PHE B 132
 None
 0.75A 5cxvA-4xydB:
undetectable		 5cxvA-4xydB:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 GLY A 391
ILE A 262
PHE A 248
GLY A 244
THR A 328
 None
 1.27A 5eslA-4xydA:
undetectable		 5eslA-4xydA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 9 ILE A 321
LEU A 315
THR A 388
ILE A 330
GLY A 391
 None
 1.43A 5ifuB-4xydA:
undetectable		 5ifuB-4xydA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans) 		5 / 9 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.31A 5mvnB-4xydA:
2.4		 5mvnB-4xydA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans) 		5 / 10 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.32A 5mvnD-4xydA:
1.8		 5mvnD-4xydA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans) 		5 / 10 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.32A 5mzrA-4xydA:
1.8		 5mzrA-4xydA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans) 		5 / 10 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.32A 5mzrC-4xydA:
2.2		 5mzrC-4xydA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN
(Roseobacter
denitrificans) 		5 / 9 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.35A 5mzrD-4xydA:
2.2		 5mzrD-4xydA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 11 HIS A 334
HIS A 246
HIS A 245
SER A 264
HIS A 316
 HEM  A 504 (-3.1A)
FE  A 505 ( 3.0A)
FE  A 505 ( 3.1A)
HEM  A 504 ( 4.1A)
HEM  A 504 (-3.6A)
 1.44A 5z0gA-4xydA:
undetectable
5z0gB-4xydA:
undetectable		 5z0gA-4xydA:
9.65
5z0gB-4xydA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 11 HIS A 334
HIS A 246
HIS A 245
SER A 264
HIS A 316
 HEM  A 504 (-3.1A)
FE  A 505 ( 3.0A)
FE  A 505 ( 3.1A)
HEM  A 504 ( 4.1A)
HEM  A 504 (-3.6A)
 1.42A 5z0jA-4xydA:
undetectable
5z0jB-4xydA:
undetectable		 5z0jA-4xydA:
9.65
5z0jB-4xydA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		5 / 12 VAL A 192
VAL A 193
PHE A 339
LEU A 168
THR A 200
 None
None
HEM  A 504 ( 3.8A)
None
None
 1.22A 6b52A-4xydA:
undetectable		 6b52A-4xydA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4xyd NORC-LIKE PROTEIN
(Roseobacter
denitrificans) 		4 / 4 GLY B  80
ARG B  85
ASN B  81
LEU B 133
 None
HEC  B 201 (-3.6A)
None
None
 1.21A 6b58A-4xydB:
undetectable		 6b58A-4xydB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		3 / 3 HIS A 194
HIS A 245
HIS A 246
 FE  A 505 (-2.9A)
FE  A 505 ( 3.1A)
FE  A 505 ( 3.0A)
 0.67A 6giqa-4xydA:
30.5		 6giqa-4xydA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		3 / 3 TRP A 196
ILE A  58
GLU A 122
 None
None
CA  A 503 (-2.5A)
 0.75A 6hcxA-4xydA:
undetectable		 6hcxA-4xydA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
(Roseobacter
denitrificans) 		4 / 7 ALA A 342
GLY A 341
LEU A 304
GLY A 313
 HEM  A 504 ( 3.7A)
None
None
HEM  A 504 (-3.3A)
 0.68A 6nm4A-4xydA:
undetectable		 6nm4A-4xydA:
16.52