SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3001_1
(SERUM ALBUMIN)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		5 / 11 LEU A  73
ARG A 135
LEU A  86
HIS A 127
ALA A 145
 None
 1.11A 1hk1A-4xyiA:
undetectable		 1hk1A-4xyiA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		5 / 11 LEU A  73
ARG A 135
LEU A  86
HIS A 127
ALA A 145
 None
 1.28A 1hk3A-4xyiA:
undetectable		 1hk3A-4xyiA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		5 / 10 ASP A 344
VAL A 382
GLY A 377
GLY A 376
THR A 340
 None
 1.10A 1k6cA-4xyiA:
undetectable		 1k6cA-4xyiA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		4 / 6 LEU A 242
VAL A 274
VAL A 284
ILE A 259
 None
 1.19A 2hyyB-4xyiA:
undetectable		 2hyyB-4xyiA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		5 / 10 SER A 386
ASN A 327
GLY A 283
ALA A 285
GLN A 239
 None
 1.24A 2x2iB-4xyiA:
undetectable		 2x2iB-4xyiA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		5 / 12 LEU A  72
LEU A  74
GLN A  87
VAL A 122
PHE A 136
 None
 1.24A 2yloA-4xyiA:
undetectable		 2yloA-4xyiA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		4 / 6 LEU A 242
VAL A 274
VAL A 284
ILE A 259
 None
 1.20A 3k5vA-4xyiA:
undetectable		 3k5vA-4xyiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		4 / 6 LEU A 242
VAL A 274
VAL A 284
ILE A 259
 None
 1.25A 3k5vB-4xyiA:
undetectable		 3k5vB-4xyiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		4 / 5 THR A 249
ILE A 259
PHE A 286
LEU A 257
 None
 1.31A 3tf1A-4xyiA:
undetectable		 3tf1A-4xyiA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		4 / 6 SER A 298
GLU A 324
VAL A 251
THR A 256
 None
 1.21A 4lnxA-4xyiA:
undetectable		 4lnxA-4xyiA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		5 / 12 LEU A 185
GLY A 184
VAL A 206
HIS A 260
THR A 249
 None
 1.13A 4olmA-4xyiA:
undetectable		 4olmA-4xyiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		4 / 8 LEU A 318
VAL A 325
TRP A 330
LEU A 305
 None
 1.12A 4pwdC-4xyiA:
undetectable		 4pwdC-4xyiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		5 / 12 GLY A 184
GLY A 182
ASN A 132
THR A 262
ALA A 196
 None
 1.11A 4uckB-4xyiA:
undetectable		 4uckB-4xyiA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		4 / 7 LEU A 247
ALA A 196
LEU A 195
TRP A 207
 None
 1.11A 5nwvA-4xyiA:
undetectable		 5nwvA-4xyiA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		3 / 3 PRO A 265
SER A 267
SER A 268
 None
 0.65A 6bpyA-4xyiA:
undetectable		 6bpyA-4xyiA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		5 / 12 THR A 317
THR A 340
VAL A 347
SER A 298
VAL A 281
 None
 1.27A 6bzoC-4xyiA:
undetectable		 6bzoC-4xyiA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xyi KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
japonicus) 		4 / 6 LEU A  37
PHE A 373
MET A 374
GLY A 376
 None
 1.05A 6hd4B-4xyiA:
undetectable		 6hd4B-4xyiA:
11.40