SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 5 PHE B 146
PHE B 142
LEU B 173
PHE B 177
 None
 1.38A 2y69C-4xymB:
undetectable
2y69J-4xymB:
undetectable		 2y69C-4xymB:
18.66
2y69J-4xymB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 6 PHE B 146
PHE B 142
LEU B 173
PHE B 177
 None
 1.13A 3ablP-4xymB:
undetectable
3ablW-4xymB:
undetectable		 3ablP-4xymB:
18.66
3ablW-4xymB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 5 PHE B 146
PHE B 142
LEU B 173
PHE B 177
 None
 1.35A 3ag3C-4xymB:
undetectable
3ag3J-4xymB:
undetectable		 3ag3C-4xymB:
18.66
3ag3J-4xymB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.42A 3k37B-4xymB:
undetectable		 3k37B-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.41A 3k39A-4xymB:
undetectable		 3k39A-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.42A 3k39B-4xymB:
undetectable		 3k39B-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.41A 3k39C-4xymB:
undetectable		 3k39C-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.41A 3k39D-4xymB:
undetectable		 3k39D-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.43A 3k39E-4xymB:
undetectable		 3k39E-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.43A 3k39F-4xymB:
undetectable		 3k39F-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.41A 3k39G-4xymB:
undetectable		 3k39G-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.42A 3k39H-4xymB:
undetectable		 3k39H-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.42A 3k39I-4xymB:
undetectable		 3k39I-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.41A 3k39J-4xymB:
undetectable		 3k39J-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.41A 3k39K-4xymB:
undetectable		 3k39K-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.43A 3k39L-4xymB:
undetectable		 3k39L-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.43A 3k39M-4xymB:
undetectable		 3k39M-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.43A 3k39N-4xymB:
undetectable		 3k39N-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ARG B  51
GLU B  44
ALA B  88
GLU B  43
ARG B  90
 None
 1.42A 3k39P-4xymB:
undetectable		 3k39P-4xymB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 ARG B  80
PRO B 116
PHE B 113
 None
None
A12  B 300 (-3.6A)
 1.03A 3thrC-4xymB:
undetectable		 3thrC-4xymB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 6 PHE B 146
PHE B 142
LEU B 173
PHE B 177
 None
 1.04A 3wg7P-4xymB:
undetectable
3wg7W-4xymB:
undetectable		 3wg7P-4xymB:
18.66
3wg7W-4xymB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ALA B 187
ILE B 220
ASP B 184
LEU B 138
ILE B 165
 None
 1.11A 4km0B-4xymB:
undetectable		 4km0B-4xymB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 6 VAL B  96
ALA B 103
GLN B  65
VAL B  66
 None
 1.06A 5i8fA-4xymB:
undetectable		 5i8fA-4xymB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 5 PHE B 146
PHE B 142
LEU B 173
PHE B 177
 None
 1.29A 5wauC-4xymB:
undetectable
5wauJ-4xymB:
undetectable		 5wauC-4xymB:
18.66
5wauJ-4xymB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 5 PHE B 146
PHE B 142
LEU B 173
PHE B 177
 None
 1.29A 5wauc-4xymB:
undetectable
5wauj-4xymB:
undetectable		 5wauc-4xymB:
18.66
5wauj-4xymB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 4 LYS B  11
LEU B   7
ALA B  10
LEU B   6
 None
 1.46A 6gnrB-4xymB:
undetectable		 6gnrB-4xymB:
21.21