SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		5 / 12 ILE A 325
ILE A 335
VAL A 163
ILE A  23
ILE A 105
 None
 0.96A 1r5lA-4xywA:
undetectable		 1r5lA-4xywA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		4 / 8 TRP A  19
LEU A 258
GLY A 257
LEU A 263
 None
 0.91A 1ya4A-4xywA:
3.2		 1ya4A-4xywA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		4 / 8 ALA A 269
GLY A 286
SER A 320
ALA A 319
 None
 0.92A 2vh3B-4xywA:
undetectable		 2vh3B-4xywA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		5 / 10 TYR A 332
ILE A  27
SER A 164
ASN A 165
TRP A  19
 None
 1.48A 3burA-4xywA:
undetectable		 3burA-4xywA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		5 / 10 TYR A 332
ILE A  27
SER A 164
ASN A 165
TRP A  19
 None
 1.45A 3burB-4xywA:
undetectable		 3burB-4xywA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		5 / 10 PHE A 306
ILE A 305
ILE A 270
LEU A 178
SER A 208
 None
 1.27A 3qgzA-4xywA:
undetectable		 3qgzA-4xywA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		3 / 3 ASP A 303
LYS A 304
ASP A 307
 None
 0.74A 4a7tA-4xywA:
undetectable		 4a7tA-4xywA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4e3aA-4xywA:
6.3		 4e3aA-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.41A 4jkuB-4xywA:
4.9		 4jkuB-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.39A 4k8pA-4xywA:
6.0		 4k8pA-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4k8pB-4xywA:
6.2		 4k8pB-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4k8tA-4xywA:
5.8		 4k8tA-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.38A 4k8tB-4xywA:
6.3		 4k8tB-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4k93A-4xywA:
5.2		 4k93A-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4k93B-4xywA:
6.0		 4k93B-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4k9cA-4xywA:
5.8		 4k9cA-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4k9cB-4xywA:
5.8		 4k9cB-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4k9iA-4xywA:
5.9		 4k9iA-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.39A 4k9iB-4xywA:
6.2		 4k9iB-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.42A 4kadA-4xywA:
6.2		 4kadA-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4kadB-4xywA:
5.4		 4kadB-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.39A 4lbxA-4xywA:
5.8		 4lbxA-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.39A 4lbxB-4xywA:
5.8		 4lbxB-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4lc4A-4xywA:
6.2		 4lc4A-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		6 / 12 GLY A 278
GLY A 279
ASN A 144
SER A 255
LEU A 251
ASP A 145
 None
 1.40A 4lc4B-4xywA:
4.9		 4lc4B-4xywA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		3 / 3 VAL A 163
TYR A 328
ALA A 331
 None
 0.51A 4ybnA-4xywA:
undetectable		 4ybnA-4xywA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		4 / 4 ILE A 105
GLY A   5
ILE A 336
LEU A  82
 None
 0.88A 5dzkl-4xywA:
undetectable
5dzkz-4xywA:
undetectable		 5dzkl-4xywA:
19.41
5dzkz-4xywA:
0.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		4 / 7 HIS A 244
ILE A 270
TYR A 309
ARG A 313
 None
 1.21A 5kkzC-4xywA:
undetectable
5kkzE-4xywA:
undetectable		 5kkzC-4xywA:
20.88
5kkzE-4xywA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		4 / 7 HIS A 244
ILE A 270
TYR A 309
ARG A 313
 None
 1.21A 5kkzK-4xywA:
undetectable
5kkzQ-4xywA:
undetectable		 5kkzK-4xywA:
20.18
5kkzQ-4xywA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		3 / 3 LEU A 258
ASN A 287
LEU A 290
 None
 0.74A 6exiD-4xywA:
5.7		 6exiD-4xywA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH
(Escherichia
coli) 		4 / 6 GLN A 315
GLU A 285
HIS A 266
ALA A 319
 None
 1.01A 6f6jC-4xywA:
undetectable
6f6jD-4xywA:
undetectable		 6f6jC-4xywA:
20.88
6f6jD-4xywA:
20.88