SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xz3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 7 LYS A 240
ALA A 241
SER A 183
SER A 160
 None
 1.08A 1dvxA-4xz3A:
undetectable		 1dvxA-4xz3A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 8 PHE A 156
MET A 209
PHE A 284
LEU A 163
 None
 1.19A 1ea1A-4xz3A:
undetectable		 1ea1A-4xz3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 7 VAL A 182
SER A 180
LEU A 190
PHE A 198
 None
 1.11A 2f78A-4xz3A:
1.8		 2f78A-4xz3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 11 GLY A 214
ILE A 239
ALA A 283
THR A 287
ILE A 236
 None
 0.92A 2nnhA-4xz3A:
undetectable		 2nnhA-4xz3A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 11 PRO A  44
MET A  53
GLY A  17
LEU A  33
VAL A  72
 None
None
COA  A 501 (-3.3A)
None
None
 1.49A 2uvnB-4xz3A:
undetectable		 2uvnB-4xz3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ILE A 176
GLY A 177
ALA A 136
ALA A 155
VAL A 154
 None
 1.07A 3jb3A-4xz3A:
undetectable		 3jb3A-4xz3A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 6 PHE A 318
LEU A 380
ALA A 376
LEU A 325
 None
 0.93A 3t3zA-4xz3A:
undetectable		 3t3zA-4xz3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 6 PHE A 318
LEU A 380
ALA A 376
LEU A 325
 None
 0.92A 3t3zB-4xz3A:
undetectable		 3t3zB-4xz3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 6 PHE A 318
LEU A 380
ALA A 376
LEU A 325
 None
 0.88A 3t3zD-4xz3A:
undetectable		 3t3zD-4xz3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 7 PRO A 328
VAL A 374
LEU A 377
ILE A 350
 None
 0.98A 3u5kB-4xz3A:
undetectable		 3u5kB-4xz3A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 8 PRO A 328
VAL A 374
LEU A 377
ILE A 350
 None
 0.91A 3u5kC-4xz3A:
undetectable		 3u5kC-4xz3A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 8 PRO A 328
VAL A 374
LEU A 377
ILE A 350
 None
 0.82A 3u5kD-4xz3A:
undetectable		 3u5kD-4xz3A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ALA A 451
LEU A 447
MET A 444
THR A 378
ALA A 376
 None
 1.10A 3ut5B-4xz3A:
undetectable		 3ut5B-4xz3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 PRO A 296
ASP A 375
GLU A 299
 None
 0.71A 3v4tC-4xz3A:
1.5		 3v4tC-4xz3A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 ILE A 181
ALA A 136
LEU A 150
SER A 291
ASN A 175
 None
 1.37A 4gh8B-4xz3A:
undetectable		 4gh8B-4xz3A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 7 TYR A 361
VAL A 411
ILE A 400
ALA A 399
 None
 0.82A 4lv9B-4xz3A:
3.2		 4lv9B-4xz3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 TYR A 121
ALA A 118
ALA A  71
ALA A  90
GLY A  91
 None
 1.09A 4oaeA-4xz3A:
undetectable		 4oaeA-4xz3A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 LEU A 163
GLY A 164
THR A 171
ILE A 178
VAL A 149
 None
 1.36A 4okwA-4xz3A:
undetectable		 4okwA-4xz3A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 4 LEU A 447
ILE A 295
PRO A 235
LEU A 275
 None
 1.13A 5eb3A-4xz3A:
3.9		 5eb3A-4xz3A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 LEU A 196
TYR A 133
ILE A  98
GLY A 145
PHE A   8
 None
None
COA  A 501 (-4.1A)
None
None
 1.23A 5eshA-4xz3A:
undetectable		 5eshA-4xz3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		5 / 9 LEU A 126
LEU A 190
ALA A  71
VAL A  92
MET A 123
 None
 1.39A 5g44A-4xz3A:
undetectable		 5g44A-4xz3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 8 PRO A 328
VAL A 374
LEU A 377
ILE A 350
 None
 0.92A 5y1yA-4xz3A:
undetectable		 5y1yA-4xz3A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 6 LEU A 380
THR A 305
CYH A 382
GLY A 307
 None
None
None
ACP  A 502 (-3.5A)
 1.09A 6gtqB-4xz3A:
undetectable
6gtqD-4xz3A:
undetectable		 6gtqB-4xz3A:
16.03
6gtqD-4xz3A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)
(Candidatus
Korarchaeum
cryptofilum) 		4 / 8 VAL A 379
ASN A 348
PRO A 349
ILE A 350
 None
 1.10A 6hzpA-4xz3A:
undetectable		 6hzpA-4xz3A:
21.85