SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 TRP A 204
TRP A 231
GLY A 233
ASN A 221
 None
 1.23A 1dedA-4xz6A:
undetectable		 1dedA-4xz6A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 LEU A 269
PHE A 106
HIS A  53
TYR A  87
GLU A  98
 None
TMO  A 401 (-4.4A)
None
None
None
 1.46A 1mmkA-4xz6A:
undetectable		 1mmkA-4xz6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 VAL A  76
TRP A 281
VAL A  74
 None
 0.98A 2izqC-4xz6A:
undetectable
2izqD-4xz6A:
undetectable		 2izqC-4xz6A:
4.83
2izqD-4xz6A:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 5 ARG A 184
PRO A 239
GLY A 262
TRP A 241
 None
 1.39A 2y7kB-4xz6A:
9.6		 2y7kB-4xz6A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 ASP A  46
GLY A  93
PRO A  51
ILE A  50
ILE A  48
 None
 0.99A 3s56B-4xz6A:
undetectable		 3s56B-4xz6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 GLY A 173
ASP A 172
LEU A 178
TRP A 177
ALA A 202
 None
None
None
TMO  A 401 (-3.7A)
None
 1.09A 4lg1A-4xz6A:
undetectable		 4lg1A-4xz6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 GLY A 173
ASP A 172
LEU A 178
TRP A 177
ALA A 202
 None
None
None
TMO  A 401 (-3.7A)
None
 1.09A 4lg1C-4xz6A:
undetectable		 4lg1C-4xz6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 TRP A  55
ILE A  52
SER A  62
 TMO  A 401 ( 3.8A)
None
None
 0.98A 5gqbA-4xz6A:
undetectable		 5gqbA-4xz6A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 LEU A  99
ILE A 291
HIS A 125
GLU A  77
VAL A  79
 None
 1.49A 5igzA-4xz6A:
undetectable		 5igzA-4xz6A:
21.41