SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		4 / 7 SER A  68
PHE A  74
THR A 111
VAL A 110
 None
 1.04A 1fo4B-4xz7A:
undetectable		 1fo4B-4xz7A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		3 / 3 ARG A 173
ASP A 127
ASN A 101
 None
 0.96A 1nbhA-4xz7A:
undetectable		 1nbhA-4xz7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		3 / 3 ARG A 173
ASP A 127
ASN A 101
 None
 0.94A 1nbhD-4xz7A:
undetectable		 1nbhD-4xz7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		3 / 3 VAL A 262
ALA A 263
HIS A 368
 None
 0.70A 1q23J-4xz7A:
undetectable		 1q23J-4xz7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		4 / 8 ALA A 427
SER A 419
LEU A 420
VAL A 421
 None
 0.83A 2bxgA-4xz7A:
undetectable		 2bxgA-4xz7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		5 / 11 SER A 243
LEU A 318
PHE A 313
ALA A 312
THR A 308
 None
 1.37A 2v0mD-4xz7A:
undetectable		 2v0mD-4xz7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		4 / 8 ILE A 120
LEU A  94
PHE A  97
GLY A  86
 None
 0.79A 2vdbA-4xz7A:
undetectable		 2vdbA-4xz7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		5 / 12 PHE A 369
ALA A 309
ALA A 257
VAL A 323
THR A 335
 None
 1.06A 3c6gA-4xz7A:
undetectable		 3c6gA-4xz7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		5 / 12 PHE A 369
ALA A 309
ALA A 257
VAL A 323
THR A 335
 None
 1.09A 3c6gB-4xz7A:
undetectable		 3c6gB-4xz7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		5 / 12 PHE A 369
ALA A 309
ALA A 257
VAL A 323
THR A 335
 None
 1.12A 3czhA-4xz7A:
undetectable		 3czhA-4xz7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		5 / 12 PHE A 369
ALA A 309
ALA A 257
VAL A 323
THR A 335
 None
 1.14A 3czhB-4xz7A:
undetectable		 3czhB-4xz7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		4 / 5 TYR A 268
ALA A 293
ALA A 263
TYR A 261
 None
 0.93A 3d91A-4xz7A:
undetectable		 3d91A-4xz7A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		5 / 12 ALA A 300
ILE A 236
LEU A 239
VAL A 262
VAL A 259
 None
 0.84A 4nkvB-4xz7A:
undetectable		 4nkvB-4xz7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		5 / 12 VAL A 303
SER A 306
ALA A 312
VAL A 294
ALA A 300
 None
 1.12A 5kirB-4xz7A:
undetectable		 5kirB-4xz7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		3 / 3 LEU A  94
LEU A  64
ARG A  91
 None
 0.70A 6fgcA-4xz7A:
undetectable		 6fgcA-4xz7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		5 / 12 THR A 266
VAL A 262
VAL A 259
PHE A 313
VAL A 303
 None
 1.45A 6iblA-4xz7A:
undetectable		 6iblA-4xz7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
suis) 		5 / 12 THR A 266
VAL A 262
VAL A 259
PHE A 313
VAL A 303
 None
 1.42A 6iblB-4xz7A:
undetectable		 6iblB-4xz7A:
21.30