SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		5 / 9 ALA A  75
ASN A 407
GLY A 388
PHE A 327
GLY A 330
 None
 1.23A 1ru9H-4xz8A:
undetectable
1ru9L-4xz8A:
undetectable		 1ru9H-4xz8A:
17.29
1ru9L-4xz8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		5 / 10 ALA A  75
ASN A 407
GLY A 388
PHE A 327
GLY A 330
 None
 1.18A 1ruaH-4xz8A:
undetectable
1ruaL-4xz8A:
undetectable		 1ruaH-4xz8A:
17.29
1ruaL-4xz8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		4 / 8 SER A 304
TYR A 307
TYR A 114
HIS A 371
 None
 1.32A 2bteD-4xz8A:
undetectable		 2bteD-4xz8A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		4 / 5 LEU A 452
GLN A 159
THR A 472
THR A 413
 None
 1.22A 2zj0C-4xz8A:
undetectable		 2zj0C-4xz8A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		4 / 5 LEU A 452
GLN A 159
THR A 472
THR A 413
 None
 1.16A 3ce6B-4xz8A:
undetectable		 3ce6B-4xz8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		5 / 9 ARG A 195
ASP A 199
ALA A 207
ILE A 216
GLY A 214
 None
 1.20A 3el4B-4xz8A:
undetectable		 3el4B-4xz8A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		4 / 6 ILE A 296
ASN A 220
PRO A 122
LEU A 127
 None
 1.11A 3oi8A-4xz8A:
undetectable		 3oi8A-4xz8A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		3 / 3 TRP A  95
VAL A  89
TRP A 137
 None
 1.10A 3zq8C-4xz8A:
undetectable
3zq8D-4xz8A:
undetectable		 3zq8C-4xz8A:
4.58
3zq8D-4xz8A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		5 / 12 LEU A  17
ILE A   5
ILE A  77
TYR A 143
TYR A 306
 None
 1.46A 4a79B-4xz8A:
undetectable		 4a79B-4xz8A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		4 / 8 LEU A  82
SER A  84
PHE A 387
TYR A 459
 None
 0.81A 4drjB-4xz8A:
undetectable		 4drjB-4xz8A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		5 / 11 LEU A  26
LEU A  13
ARG A  10
TYR A 459
THR A  31
 None
 1.32A 4i1nA-4xz8A:
undetectable		 4i1nA-4xz8A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		3 / 3 LYS A 406
LEU A 385
ALA A 405
 None
 0.80A 4iizA-4xz8A:
undetectable		 4iizA-4xz8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		5 / 12 THR A 283
ALA A 232
LEU A 234
MET A 225
LEU A 224
 None
 1.11A 4xi3A-4xz8A:
undetectable		 4xi3A-4xz8A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		4 / 7 ILE A 390
TYR A 459
ALA A  75
ILE A  77
 None
 0.78A 4y03A-4xz8A:
2.5		 4y03A-4xz8A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		5 / 12 MET A  88
VAL A 141
TRP A 137
LEU A  82
LEU A 146
 None
 1.01A 5im2A-4xz8A:
undetectable		 5im2A-4xz8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		5 / 12 LEU A 380
TRP A 350
SER A 402
GLY A 388
GLY A 330
 None
 1.20A 5nnaC-4xz8A:
undetectable		 5nnaC-4xz8A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		4 / 8 GLY A 467
ASN A 294
GLN A 295
ALA A 462
 None
 0.91A 5xu8A-4xz8A:
undetectable		 5xu8A-4xz8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4xz8 NUCLEOPROTEIN
(Thiafora
orthonairovirus) 		4 / 7 ALA A  74
GLY A 401
ASN A  32
THR A  31
 None
 0.75A 5ybbB-4xz8A:
undetectable		 5ybbB-4xz8A:
21.94