SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 7 TYR A 137
THR A  34
GLU A 231
MET A 125
 None
 0.81A 1tv8B-4xzbA:
4.7		 1tv8B-4xzbA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 5 TRP A 262
ILE A 252
ALA A 306
GLU A 305
 None
 1.08A 1xvaA-4xzbA:
undetectable
1xvaB-4xzbA:
undetectable		 1xvaA-4xzbA:
20.90
1xvaB-4xzbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 12 ASN A 141
GLU A 142
HIS A 203
GLU A 231
TRP A 265
 None
 0.61A 2v3dA-4xzbA:
16.6		 2v3dA-4xzbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		3 / 3 TYR A 205
GLU A 142
ASN A 107
 None
 0.77A 2y7hC-4xzbA:
undetectable		 2y7hC-4xzbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		3 / 3 SER A 274
GLU A 142
ASP A 184
 None
 0.76A 2zulA-4xzbA:
undetectable		 2zulA-4xzbA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 12 ARG A  62
GLU A 138
TYR A 205
ASN A 141
HIS A 104
 None
 1.47A 3bjmA-4xzbA:
undetectable		 3bjmA-4xzbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 12 ARG A  62
GLU A 138
TYR A 205
ASN A 141
HIS A 104
 None
 1.44A 3bjmB-4xzbA:
undetectable		 3bjmB-4xzbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		3 / 3 SER A 274
GLU A 142
ASP A 184
 None
 0.82A 3dmhA-4xzbA:
undetectable		 3dmhA-4xzbA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 7 PHE A 298
PHE A 204
SER A 206
TYR A 205
 None
 1.43A 3hggA-4xzbA:
undetectable		 3hggA-4xzbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 12 THR A  67
ASP A  68
GLY A 145
VAL A 148
ASN A 141
 None
 1.50A 3hiiB-4xzbA:
undetectable		 3hiiB-4xzbA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		3 / 3 HIS A 104
PHE A 121
PHE A 122
 None
 0.48A 3lk0D-4xzbA:
0.3		 3lk0D-4xzbA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 8 PRO A 143
HIS A 104
ILE A 105
ILE A 139
 None
 0.87A 3sfeB-4xzbA:
undetectable
3sfeC-4xzbA:
undetectable		 3sfeB-4xzbA:
19.94
3sfeC-4xzbA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 9 SER A 182
THR A 180
ASN A 144
GLY A 145
ASP A 147
 None
 1.20A 3sfuA-4xzbA:
undetectable		 3sfuA-4xzbA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 7 LEU A  81
GLY A  88
ALA A  44
PHE A  49
 None
 1.01A 3tehB-4xzbA:
undetectable		 3tehB-4xzbA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		3 / 3 PHE A  40
CYH A 268
HIS A  35
 None
 0.94A 3u9fF-4xzbA:
undetectable		 3u9fF-4xzbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		3 / 3 PHE A  40
CYH A 268
HIS A  35
 None
 0.92A 3u9fG-4xzbA:
undetectable		 3u9fG-4xzbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		3 / 3 PHE A  40
CYH A 268
HIS A  35
 None
 0.82A 3u9fL-4xzbA:
undetectable		 3u9fL-4xzbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		3 / 3 PHE A  40
CYH A 268
HIS A  35
 None
 0.98A 3u9fS-4xzbA:
undetectable		 3u9fS-4xzbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 12 ARG A  62
GLU A 138
TYR A 205
ASN A 141
HIS A 104
 None
 1.47A 3w2tA-4xzbA:
undetectable		 3w2tA-4xzbA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 12 ARG A  62
GLU A 138
TYR A 205
ASN A 141
HIS A 104
 None
 1.41A 3w2tB-4xzbA:
undetectable		 3w2tB-4xzbA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 6 HIS A 203
GLU A 231
ASP A 102
SER A  33
 None
 1.09A 4apjA-4xzbA:
undetectable
4apjP-4xzbA:
undetectable		 4apjA-4xzbA:
20.30
4apjP-4xzbA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 5 GLN A  42
THR A  51
LEU A 292
LEU A 277
 None
 1.10A 4lvcB-4xzbA:
undetectable		 4lvcB-4xzbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		3 / 3 PRO A 226
VAL A 202
HIS A 203
 None
 0.83A 4pevC-4xzbA:
undetectable		 4pevC-4xzbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		6 / 12 SER A  33
GLY A 177
SER A 182
GLU A 142
ASN A 141
ALA A 158
 None
 1.44A 4u95B-4xzbA:
undetectable		 4u95B-4xzbA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 9 SER A  33
GLY A 177
SER A 182
GLU A 142
ALA A 158
 None
 1.43A 5entC-4xzbA:
undetectable		 5entC-4xzbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 6 GLY A 233
THR A 234
SER A 235
ASN A 264
 None
 0.85A 5k4pA-4xzbA:
undetectable		 5k4pA-4xzbA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 6 ILE A 260
ILE A  32
LEU A 303
PHE A  49
 None
 0.87A 5vkqA-4xzbA:
undetectable
5vkqB-4xzbA:
undetectable		 5vkqA-4xzbA:
9.70
5vkqB-4xzbA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		4 / 6 PHE A  49
ILE A 260
ILE A  32
LEU A 303
 None
 0.85A 5vkqA-4xzbA:
undetectable
5vkqD-4xzbA:
undetectable		 5vkqA-4xzbA:
9.70
5vkqD-4xzbA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 10 LEU A 245
LEU A 303
LEU A 267
ALA A 276
LEU A 292
 None
 1.23A 5y7pD-4xzbA:
undetectable		 5y7pD-4xzbA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 12 ARG A  62
GLU A 138
TYR A 205
ASN A 141
HIS A 104
 None
 1.44A 6b1eB-4xzbA:
undetectable		 6b1eB-4xzbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4xzb CELA
(Geobacillus
sp.
70PC53) 		5 / 9 ALA A 273
SER A 235
GLY A 242
ALA A 248
SER A 206
 None
 1.20A 6bklE-4xzbA:
undetectable
6bklF-4xzbA:
undetectable
6bklG-4xzbA:
undetectable
6bklH-4xzbA:
undetectable		 6bklE-4xzbA:
5.80
6bklF-4xzbA:
5.80
6bklG-4xzbA:
5.80
6bklH-4xzbA:
5.80