SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xzc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 4 HIS A 410
ALA A 391
PHE A 393
GLY A 394
 None
 1.41A 1mj2B-4xzcA:
undetectable		 1mj2B-4xzcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 4 HIS A 410
ALA A 391
PHE A 393
GLY A 394
 None
 1.42A 1mjoD-4xzcA:
undetectable		 1mjoD-4xzcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		5 / 12 THR A  71
GLY A 409
HIS A 410
VAL A 450
LEU A 434
 None
 0.92A 1r30B-4xzcA:
undetectable		 1r30B-4xzcA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 5 PRO A 322
GLY A  92
ASN A  91
GLY A  87
 None
 0.81A 1zlqA-4xzcA:
undetectable		 1zlqA-4xzcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 8 SER A 310
TYR A 313
TYR A 110
HIS A 377
 None
 1.34A 2bteA-4xzcA:
2.4		 2bteA-4xzcA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 8 SER A 310
TYR A 313
TYR A 110
HIS A 377
 None
 1.24A 2bteD-4xzcA:
2.8		 2bteD-4xzcA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 4 ILE A  62
GLN A 438
ILE A  45
LEU A 444
 None
 1.17A 3dzyD-4xzcA:
0.9		 3dzyD-4xzcA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 5 TYR A 144
THR A 145
PHE A 467
LEU A 415
 None
 1.20A 3qelC-4xzcA:
undetectable		 3qelC-4xzcA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		5 / 10 LEU A 328
THR A 324
LEU A 349
THR A 352
PHE A 364
 None
 1.29A 3tbgC-4xzcA:
2.5		 3tbgC-4xzcA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		3 / 3 PHE A 467
CYH A 465
HIS A 466
 None
 0.88A 3u9fF-4xzcA:
undetectable		 3u9fF-4xzcA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		3 / 3 PHE A 467
CYH A 465
HIS A 466
 None
 0.91A 3u9fG-4xzcA:
undetectable		 3u9fG-4xzcA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		3 / 3 PHE A 467
CYH A 465
HIS A 466
 None
 1.01A 3u9fL-4xzcA:
undetectable		 3u9fL-4xzcA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		3 / 3 PHE A 467
CYH A 465
HIS A 466
 None
 0.88A 3u9fS-4xzcA:
undetectable		 3u9fS-4xzcA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		3 / 3 TRP A  95
VAL A  89
TRP A 133
 None
 1.11A 3zq8C-4xzcA:
undetectable
3zq8D-4xzcA:
undetectable		 3zq8C-4xzcA:
4.15
3zq8D-4xzcA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 6 TYR A  20
PRO A 397
PHE A  36
PHE A 333
 None
 1.41A 4kf9A-4xzcA:
undetectable		 4kf9A-4xzcA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 7 PHE A 331
LEU A 332
MET A 335
ALA A 315
 None
 1.03A 4rjdB-4xzcA:
undetectable		 4rjdB-4xzcA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		5 / 12 TYR A 313
SER A 310
ALA A 125
ALA A 129
TYR A 110
 None
 1.47A 4u15A-4xzcA:
undetectable		 4u15A-4xzcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		5 / 12 GLY A 409
GLY A 336
GLY A 338
SER A 408
ALA A  75
 None
 1.01A 4uciB-4xzcA:
undetectable		 4uciB-4xzcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		3 / 3 VAL A 233
GLU A 119
GLU A 121
 None
 0.83A 5jsdB-4xzcA:
undetectable
5jsdC-4xzcA:
undetectable		 5jsdB-4xzcA:
23.15
5jsdC-4xzcA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		5 / 12 MET A 236
VAL A 239
ILE A 251
GLU A 204
THR A 254
 None
 1.39A 5w8aA-4xzcA:
undetectable		 5w8aA-4xzcA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 4xzc NUCLEOPROTEIN
(Nairobi
sheep
disease
orthonairovirus) 		4 / 5 GLN A 284
ASN A 222
THR A 280
LEU A 277
 None
 1.41A 6d8pA-4xzcA:
undetectable		 6d8pA-4xzcA:
20.23