SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		5 / 11 VAL A 330
SER A 313
TYR A 112
ALA A 320
LEU A 362
 None
 1.14A 1eqgB-4xzeA:
undetectable		 1eqgB-4xzeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		3 / 3 ASP A  97
LYS A 319
ARG A 361
 None
 1.19A 1ra8A-4xzeA:
undetectable		 1ra8A-4xzeA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		4 / 6 ALA A 208
TYR A 287
ILE A 257
LEU A 238
 None
 0.90A 1xvaA-4xzeA:
undetectable
1xvaB-4xzeA:
undetectable		 1xvaA-4xzeA:
20.53
1xvaB-4xzeA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		4 / 5 ILE A 433
SER A 173
ARG A 178
LEU A 458
 None
 1.12A 1y0xX-4xzeA:
undetectable		 1y0xX-4xzeA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		4 / 8 SER A 312
TYR A 315
TYR A 112
HIS A 379
 None
 1.29A 2bteA-4xzeA:
undetectable		 2bteA-4xzeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		4 / 8 SER A 312
TYR A 315
TYR A 112
HIS A 379
 None
 1.19A 2bteD-4xzeA:
undetectable		 2bteD-4xzeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		4 / 8 SER A 312
TYR A 315
TYR A 112
HIS A 379
 None
 1.37A 2v0gA-4xzeA:
undetectable		 2v0gA-4xzeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		4 / 5 TYR A 146
THR A 147
PHE A 469
LEU A 417
 None
 1.36A 3qelC-4xzeA:
undetectable		 3qelC-4xzeA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		3 / 3 TRP A  95
VAL A  89
TRP A 135
 None
 1.15A 3zq8C-4xzeA:
undetectable
3zq8D-4xzeA:
undetectable		 3zq8C-4xzeA:
3.73
3zq8D-4xzeA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		4 / 8 SER A 454
GLU A  51
ASP A  44
TYR A 444
 None
 1.42A 4qb9D-4xzeA:
undetectable		 4qb9D-4xzeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		5 / 12 LEU A 362
ILE A 352
PHE A 366
LEU A 337
MET A 388
 None
 1.17A 4ze2A-4xzeA:
undetectable		 4ze2A-4xzeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		5 / 9 SER A  35
ALA A 397
GLY A 409
ALA A 415
GLY A 411
 None
 1.22A 6bklE-4xzeA:
undetectable
6bklF-4xzeA:
undetectable
6bklG-4xzeA:
undetectable
6bklH-4xzeA:
undetectable		 6bklE-4xzeA:
6.01
6bklF-4xzeA:
6.01
6bklG-4xzeA:
6.01
6bklH-4xzeA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		5 / 11 VAL A 330
GLY A 396
ALA A  75
ASN A   3
VAL A 400
 None
 1.39A 6hu9A-4xzeA:
undetectable
6hu9E-4xzeA:
undetectable
6hu9I-4xzeA:
undetectable		 6hu9A-4xzeA:
25.05
6hu9E-4xzeA:
17.72
6hu9I-4xzeA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4xze NUCLEOPROTEIN
(Hazara
orthonairovirus) 		5 / 10 VAL A 330
GLY A 396
ALA A  75
ASN A   3
VAL A 400
 None
 1.45A 6hu9L-4xzeA:
undetectable
6hu9P-4xzeA:
undetectable
6hu9T-4xzeA:
undetectable		 6hu9L-4xzeA:
25.05
6hu9P-4xzeA:
17.72
6hu9T-4xzeA:
9.62