SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4xzk PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS
(Vibrio
splendidus) 		4 / 5 PRO A 138
VAL A 136
ASN A 197
VAL A 238
 None
 1.11A 1z2bC-4xzkA:
undetectable		 1z2bC-4xzkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4xzk PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS
(Vibrio
splendidus) 		4 / 6 SER A 142
SER A 144
PHE A 153
GLU A 191
 AG2  A 700 (-3.4A)
None
AG2  A 700 (-4.3A)
AG2  A 700 (-2.9A)
 1.30A 2c8aC-4xzkA:
14.1		 2c8aC-4xzkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4xzk PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS
(Vibrio
splendidus) 		3 / 3 THR A  82
SER A 234
LYS A 122
 None
 1.18A 3aocC-4xzkA:
undetectable		 3aocC-4xzkA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4xzk PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS
(Vibrio
splendidus) 		5 / 9 LEU A 126
VAL A 121
ILE A 202
LEU A 135
PHE A 169
 None
 1.35A 3fl9H-4xzkA:
undetectable		 3fl9H-4xzkA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4xzk PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS
(Vibrio
splendidus) 		5 / 11 LEU A  79
TYR A  78
PHE A  67
ILE A  98
VAL A 101
 None
 1.09A 5hjiA-4xzkA:
undetectable		 5hjiA-4xzkA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4xzk PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS
(Vibrio
splendidus) 		5 / 9 SER A 142
ALA A 115
VAL A 149
ALA A 150
GLY A 118
 AG2  A 700 (-3.4A)
None
None
None
AG2  A 700 (-4.9A)
 1.27A 6bklA-4xzkA:
undetectable
6bklB-4xzkA:
undetectable
6bklC-4xzkA:
undetectable
6bklD-4xzkA:
undetectable		 6bklA-4xzkA:
9.76
6bklB-4xzkA:
9.76
6bklC-4xzkA:
9.76
6bklD-4xzkA:
9.76