SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_L_FUAL710_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4xzp	GALECTIN-4 (Homo sapiens)	3 / 3	VAL A 60 ALA A 61 HIS A 126	None	0.66A	1q23J-4xzpA: undetectable	1q23J-4xzpA: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_D_KLND1499_1 (CYTOCHROME P450 3A4)	4xzp	GALECTIN-4 (Homo sapiens)	4 / 5	PHE A 76 PHE A 46 PHE A 121 ILE A 147	None	1.05A	2v0mD-4xzpA: undetectable	2v0mD-4xzpA: 15.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GAL_A_1GNA998_1 (GALECTIN-7)	4xzp	GALECTIN-4 (Homo sapiens)	6 / 6	HIS A 63 ASN A 65 ARG A 67 ASN A 77 TRP A 84 GLU A 87	None	0.51A	3galA-4xzpA: 22.7	3galA-4xzpA: 33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GAL_B_1GNB999_1 (GALECTIN-7)	4xzp	GALECTIN-4 (Homo sapiens)	6 / 6	HIS A 63 ASN A 65 ARG A 67 ASN A 77 TRP A 84 GLU A 87	None	0.46A	3galB-4xzpA: 22.3	3galB-4xzpA: 33.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_C_FLRC700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4xzp	GALECTIN-4 (Homo sapiens)	5 / 12	VAL A 33 VAL A 138 LEU A 17 LEU A 136 GLY A 37	None	1.00A	3rr3C-4xzpA: undetectable	3rr3C-4xzpA: 15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_D_FLRD700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4xzp	GALECTIN-4 (Homo sapiens)	5 / 12	VAL A 33 VAL A 138 LEU A 17 LEU A 136 GLY A 37	None	1.00A	3rr3D-4xzpA: undetectable	3rr3D-4xzpA: 15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B8K_A_W9TA300_0 (GALECTIN-3)	4xzp	GALECTIN-4 (Homo sapiens)	6 / 7	HIS A 63 ASN A 65 ARG A 67 ASN A 77 TRP A 84 GLU A 87	None	0.45A	6b8kA-4xzpA: 22.7	6b8kA-4xzpA: 29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B94_A_W9TA201_0 (GALECTIN-1)	4xzp	GALECTIN-4 (Homo sapiens)	6 / 8	HIS A 63 ASN A 65 ARG A 67 ASN A 77 TRP A 84 GLU A 87	None	0.53A	6b94A-4xzpA: 17.5	6b94A-4xzpA: 24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B94_B_W9TB201_0 (GALECTIN-1)	4xzp	GALECTIN-4 (Homo sapiens)	6 / 10	HIS A 63 ASN A 65 ARG A 67 ASN A 77 TRP A 84 GLU A 87	None	0.54A	6b94A-4xzpA: 17.5 6b94B-4xzpA: 17.2	6b94A-4xzpA: 24.52 6b94B-4xzpA: 24.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q23_L_FUAL710_1","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","4xzp","GALECTIN-4","Homo sapiens",3,"VAL A  60;ALA A  61;HIS A 126","None","0.66A","1q23J-4xzpA:undetectable","1q23J-4xzpA:21.40"],["2V0M_D_KLND1499_1","CYTOCHROME P450 3A4","4xzp","GALECTIN-4","Homo sapiens",4,"PHE A  76;PHE A  46;PHE A 121;ILE A 147","None","1.05A","2v0mD-4xzpA:undetectable","2v0mD-4xzpA:15.67"],["3GAL_A_1GNA998_1","GALECTIN-7","4xzp","GALECTIN-4","Homo sapiens",6,"HIS A  63;ASN A  65;ARG A  67;ASN A  77;TRP A  84;GLU A  87","None","0.51A","3galA-4xzpA:22.7","3galA-4xzpA:33.73"],["3GAL_B_1GNB999_1","GALECTIN-7","4xzp","GALECTIN-4","Homo sapiens",6,"HIS A  63;ASN A  65;ARG A  67;ASN A  77;TRP A  84;GLU A  87","None","0.46A","3galB-4xzpA:22.3","3galB-4xzpA:33.73"],["3RR3_C_FLRC700_1","PROSTAGLANDIN G\/H SYNTHASE 2","4xzp","GALECTIN-4","Homo sapiens",5,"VAL A  33;VAL A 138;LEU A  17;LEU A 136;GLY A  37","None","1.00A","3rr3C-4xzpA:undetectable","3rr3C-4xzpA:15.47"],["3RR3_D_FLRD700_1","PROSTAGLANDIN G\/H SYNTHASE 2","4xzp","GALECTIN-4","Homo sapiens",5,"VAL A  33;VAL A 138;LEU A  17;LEU A 136;GLY A  37","None","1.00A","3rr3D-4xzpA:undetectable","3rr3D-4xzpA:15.47"],["6B8K_A_W9TA300_0","GALECTIN-3","4xzp","GALECTIN-4","Homo sapiens",6,"HIS A  63;ASN A  65;ARG A  67;ASN A  77;TRP A  84;GLU A  87","None","0.45A","6b8kA-4xzpA:22.7","6b8kA-4xzpA:29.08"],["6B94_A_W9TA201_0","GALECTIN-1","4xzp","GALECTIN-4","Homo sapiens",6,"HIS A  63;ASN A  65;ARG A  67;ASN A  77;TRP A  84;GLU A  87","None","0.53A","6b94A-4xzpA:17.5","6b94A-4xzpA:24.52"],["6B94_B_W9TB201_0","GALECTIN-1","4xzp","GALECTIN-4","Homo sapiens",6,"HIS A  63;ASN A  65;ARG A  67;ASN A  77;TRP A  84;GLU A  87","None","0.54A","6b94A-4xzpA:17.5;6b94B-4xzpA:17.2","6b94A-4xzpA:24.52;6b94B-4xzpA:24.52"]]