SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xzu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4xzu COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 12 ILE M2190
ILE M2185
VAL M2243
VAL M2240
PRO M2177
 None
 1.00A 2ygpA-4xzuM:
undetectable		 2ygpA-4xzuM:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4xzu 3E6 ANTIBODY FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 5 ILE A  51
ALA A  79
HIS A  35
ARG A  98
 None
 1.02A 4ac9B-4xzuA:
undetectable
4ac9C-4xzuA:
undetectable		 4ac9B-4xzuA:
17.05
4ac9C-4xzuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4xzu 3E6 ANTIBODY FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 5 ILE A  51
ALA A  79
HIS A  35
ARG A  98
 None
 0.97A 4acaB-4xzuA:
undetectable
4acaC-4xzuA:
undetectable		 4acaB-4xzuA:
17.05
4acaC-4xzuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4xzu 3E6 ANTIBODY FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 4 ILE A  83
LEU A  81
LYS A  19
ASN A  84
 None
 1.49A 4g19D-4xzuA:
undetectable		 4g19D-4xzuA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 4xzu 3E6 ANTIBODY FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 5 SER A 115
ALA A 117
PHE A 149
LEU A 173
 None
 0.31A 5mthA-4xzuA:
27.2		 5mthA-4xzuA:
66.52