SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		5 / 11 ILE A 173
ALA A 157
ILE A 153
SER A 181
ILE A 174
 None
 1.19A 1dg5A-4xzwA:
undetectable		 1dg5A-4xzwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		4 / 8 PHE A  49
SER A  33
ARG A  62
ALA A  92
 None
 1.19A 1rqpA-4xzwA:
undetectable		 1rqpA-4xzwA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		4 / 7 TYR A 137
THR A  34
GLU A 230
MET A 125
 None
None
EPE  A 404 (-4.3A)
None
 0.89A 1tv8B-4xzwA:
4.1		 1tv8B-4xzwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		4 / 7 ARG A  30
ASP A 255
THR A 258
ASN A   9
 None
 1.08A 2jc9A-4xzwA:
1.9		 2jc9A-4xzwA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		5 / 12 ASN A 141
GLU A 142
HIS A 202
GLU A 230
TRP A 264
 None
EPE  A 404 (-3.3A)
None
EPE  A 404 (-4.3A)
EPE  A 404 ( 4.1A)
 0.54A 2v3dA-4xzwA:
17.0		 2v3dA-4xzwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		3 / 3 SER A 273
GLU A 142
ASP A 183
 None
EPE  A 404 (-3.3A)
None
 0.77A 2zulA-4xzwA:
undetectable		 2zulA-4xzwA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		3 / 3 HIS A 104
PHE A 121
PHE A 122
 None
 0.39A 3lk0D-4xzwA:
undetectable		 3lk0D-4xzwA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		4 / 8 ALA A 272
ASP A 235
ASP A 239
SER A 237
 None
 0.96A 3qj7A-4xzwA:
undetectable
3qj7D-4xzwA:
undetectable		 3qj7A-4xzwA:
22.50
3qj7D-4xzwA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		4 / 8 PRO A 143
HIS A 104
ILE A 105
ILE A 139
 None
 0.94A 3sfeB-4xzwA:
undetectable
3sfeC-4xzwA:
undetectable		 3sfeB-4xzwA:
19.52
3sfeC-4xzwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		5 / 9 SER A 181
THR A 179
ASN A 144
GLY A 145
ASP A 146
 None
 1.20A 3sfuA-4xzwA:
undetectable		 3sfuA-4xzwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		3 / 3 PHE A  40
CYH A 267
HIS A  35
 None
 0.97A 3u9fG-4xzwA:
undetectable		 3u9fG-4xzwA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		3 / 3 PHE A  40
CYH A 267
HIS A  35
 None
 1.03A 3u9fS-4xzwA:
undetectable		 3u9fS-4xzwA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		4 / 6 HIS A 202
GLU A 230
ASP A 102
SER A  33
 None
EPE  A 404 (-4.3A)
None
None
 1.06A 4apjA-4xzwA:
undetectable
4apjP-4xzwA:
undetectable		 4apjA-4xzwA:
20.20
4apjP-4xzwA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		4 / 5 TYR A 137
ILE A 139
ASN A 196
ILE A 161
 None
 1.06A 4jtpA-4xzwA:
undetectable		 4jtpA-4xzwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		4 / 8 SER A 234
SER A 273
TRP A 264
GLU A 230
 None
None
EPE  A 404 ( 4.1A)
EPE  A 404 (-4.3A)
 1.30A 4ms4A-4xzwA:
undetectable		 4ms4A-4xzwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		4 / 5 ASN A 141
HIS A 104
GLU A 138
THR A 229
 None
 1.42A 4p6sA-4xzwA:
undetectable		 4p6sA-4xzwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		6 / 12 SER A  33
GLY A 176
SER A 181
GLU A 142
ASN A 141
ALA A 157
 None
None
None
EPE  A 404 (-3.3A)
None
None
 1.45A 4u95B-4xzwA:
undetectable		 4u95B-4xzwA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		5 / 12 PRO A 111
ILE A 153
TYR A 199
VAL A 184
THR A 229
 None
 1.41A 4xe0A-4xzwA:
undetectable		 4xe0A-4xzwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		4 / 7 LEU A 244
SER A 247
GLY A 232
ALA A 205
 None
 0.72A 4yjiA-4xzwA:
undetectable		 4yjiA-4xzwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		5 / 9 SER A  33
GLY A 176
SER A 181
GLU A 142
ALA A 157
 None
None
None
EPE  A 404 (-3.3A)
None
 1.44A 5entC-4xzwA:
undetectable		 5entC-4xzwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		5 / 12 ASP A 185
THR A 207
GLN A 246
PHE A 211
GLY A 209
 None
EPE  A 404 (-4.0A)
None
None
None
 1.12A 5hfjC-4xzwA:
undetectable		 5hfjC-4xzwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		4 / 6 GLY A 232
THR A 233
SER A 234
ASN A 263
 None
 0.81A 5k4pA-4xzwA:
undetectable		 5k4pA-4xzwA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		4 / 6 ILE A 259
ILE A  32
LEU A 302
PHE A  49
 None
 0.94A 5vkqA-4xzwA:
undetectable
5vkqB-4xzwA:
undetectable		 5vkqA-4xzwA:
10.73
5vkqB-4xzwA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		4 / 6 PHE A  49
ILE A 259
ILE A  32
LEU A 302
 None
 0.91A 5vkqA-4xzwA:
undetectable
5vkqD-4xzwA:
undetectable		 5vkqA-4xzwA:
10.73
5vkqD-4xzwA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(Geobacillus
sp.
70PC53;
uncultured
bacterium) 		4 / 6 MET A  65
ASN A  45
LEU A  81
GLN A  42
 None
 1.45A 5xdhA-4xzwA:
undetectable
5xdhC-4xzwA:
undetectable		 5xdhA-4xzwA:
13.95
5xdhC-4xzwA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		3 / 3 THR A 229
GLU A 138
HIS A 104
 None
 0.89A 5xiqB-4xzwA:
undetectable		 5xiqB-4xzwA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		3 / 3 THR A 229
GLU A 138
HIS A 104
 None
 0.91A 5xiqD-4xzwA:
undetectable		 5xiqD-4xzwA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4xzw ENDO-GLUCANASE
CHIMERA C10
(uncultured
bacterium;
Geobacillus
sp.
70PC53) 		4 / 8 ASP A 293
HIS A 290
ARG A 296
ASP A 288
 None
 1.20A 6mn4A-4xzwA:
undetectable		 6mn4A-4xzwA:
21.89