SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		4 / 4 LEU A 493
ILE A 259
ARG A 258
TYR A 581
 None
 1.24A 1rk3A-4y05A:
undetectable		 1rk3A-4y05A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		4 / 8 GLU A 272
ARG A 264
HIS A 356
GLU A 317
 None
ADP  A 702 (-3.9A)
ADP  A 702 (-3.5A)
None
 1.28A 1s3zA-4y05A:
undetectable
1s3zB-4y05A:
undetectable		 1s3zA-4y05A:
18.31
1s3zB-4y05A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		4 / 5 LEU A 493
ILE A 259
ARG A 258
TYR A 581
 None
 1.25A 2zlcA-4y05A:
undetectable		 2zlcA-4y05A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		3 / 3 PRO A 284
PHE A 311
LYS A 286
 None
 1.28A 3bjwG-4y05A:
undetectable		 3bjwG-4y05A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		4 / 6 GLY A 348
TYR A 581
MET A 561
ASN A 496
 None
 0.97A 3e9rC-4y05A:
undetectable		 3e9rC-4y05A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		4 / 6 LEU A 548
VAL A 547
PHE A 402
VAL A 491
 None
 1.12A 3soaA-4y05A:
0.7		 3soaA-4y05A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		5 / 12 ALA A 329
LYS A 341
SER A 557
ILE A 527
LEU A 530
 None
 1.08A 4ky8A-4y05A:
undetectable		 4ky8A-4y05A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		3 / 3 MET A 451
ASP A 411
PHE A 402
 None
 1.02A 4xeyA-4y05A:
undetectable		 4xeyA-4y05A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		3 / 3 MET A 451
ASP A 411
PHE A 410
 None
 1.07A 4xeyA-4y05A:
undetectable		 4xeyA-4y05A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		3 / 3 MET A 451
ASP A 411
PHE A 402
 None
 1.04A 4xeyB-4y05A:
undetectable		 4xeyB-4y05A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		3 / 3 MET A 451
ASP A 411
PHE A 410
 None
 1.00A 4xeyB-4y05A:
undetectable		 4xeyB-4y05A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		5 / 12 TYR A 347
SER A 489
ALA A 377
ALA A 329
TYR A 325
 None
 1.37A 4ymgA-4y05A:
undetectable		 4ymgA-4y05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		5 / 12 TYR A 347
SER A 489
ALA A 377
ALA A 329
TYR A 325
 None
 1.36A 4ymgB-4y05A:
undetectable		 4ymgB-4y05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		3 / 3 SER A 551
GLU A 436
GLU A 396
 None
 0.81A 4ymgB-4y05A:
undetectable		 4ymgB-4y05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		5 / 12 GLY A 353
ASP A 492
GLY A 372
THR A 328
ILE A 562
 ADP  A 702 (-3.4A)
MG  A 701 ( 3.9A)
None
None
None
 0.87A 5kqxA-4y05A:
undetectable		 5kqxA-4y05A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		3 / 3 GLY A 339
THR A 335
ASN A 556
 None
 0.62A 5odiG-4y05A:
undetectable		 5odiG-4y05A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		4 / 6 ARG A 258
GLY A 531
SER A 557
THR A 559
 None
 0.60A 5ysiA-4y05A:
undetectable		 5ysiA-4y05A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4y05 KINESIN-LIKE PROTEIN
KIF2C
(Homo
sapiens) 		5 / 12 ILE A 236
ASN A 229
SER A 570
SER A 571
LEU A 268
 None
 1.45A 6chgC-4y05A:
undetectable		 6chgC-4y05A:
17.58