SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 12 PHE A 607
ILE A 591
GLY A 609
THR A 721
GLU A 719
 None
 1.20A 1sg9A-4y07A:
undetectable		 1sg9A-4y07A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 7 HIS A 618
LEU A 544
MET A 535
ILE A 532
 None
 1.08A 1tuvA-4y07A:
undetectable		 1tuvA-4y07A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		6 / 12 PHE A 724
LEU A 745
LEU A 749
SER A 568
PHE A 630
LEU A 737
 None
 1.32A 1xdkF-4y07A:
undetectable		 1xdkF-4y07A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 7 PHE A 502
ALA A 732
LEU A 734
PHE A 740
 None
 0.88A 2vcvL-4y07A:
2.3		 2vcvL-4y07A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 SER A 528
PHE A 607
VAL A 571
PHE A 564
 None
 1.24A 2wekA-4y07A:
undetectable		 2wekA-4y07A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 SER A 528
PHE A 607
VAL A 571
PHE A 564
 None
 1.27A 2wekB-4y07A:
undetectable		 2wekB-4y07A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 12 THR A 799
THR A 837
ILE A 755
ILE A 792
LEU A 812
 None
 1.18A 3gwxA-4y07A:
undetectable		 3gwxA-4y07A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 7 TYR A 617
VAL A 519
VAL A 515
ILE A 532
 None
 1.02A 3mssB-4y07A:
undetectable		 3mssB-4y07A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 ILE A 608
VAL A 571
THR A 624
ILE A 622
 None
 0.67A 3p4wC-4y07A:
undetectable		 3p4wC-4y07A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 5 SER A 835
GLU A 865
THR A 837
ASP A 643
 None
 1.30A 3zs3A-4y07A:
undetectable		 3zs3A-4y07A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 6 GLU A 526
TYR A 604
HIS A 601
PHE A 525
 None
 1.19A 4a97E-4y07A:
undetectable		 4a97E-4y07A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 SER A 528
ILE A 517
TRP A 563
PHE A 564
 None
 1.22A 4cx7A-4y07A:
undetectable
4cx7B-4y07A:
undetectable		 4cx7A-4y07A:
22.96
4cx7B-4y07A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 SER A 528
ILE A 517
TRP A 563
PHE A 564
 None
 1.22A 4cx7C-4y07A:
0.0
4cx7D-4y07A:
undetectable		 4cx7C-4y07A:
22.96
4cx7D-4y07A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		3 / 3 LEU A 725
LYS A 722
THR A 721
 None
 0.57A 4lj0A-4y07A:
undetectable		 4lj0A-4y07A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 6 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.05A 5dzkB-4y07A:
undetectable
5dzkP-4y07A:
undetectable		 5dzkB-4y07A:
20.95
5dzkP-4y07A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.16A 5dzkF-4y07A:
undetectable
5dzkT-4y07A:
undetectable		 5dzkF-4y07A:
20.95
5dzkT-4y07A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 6 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.20A 5dzkg-4y07A:
undetectable
5dzku-4y07A:
undetectable		 5dzkg-4y07A:
20.95
5dzku-4y07A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_A_URFA301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 4 ARG A 841
ASP A 843
HIS A 768
ARG A 767
 None
 1.50A 5iaoA-4y07A:
0.1		 5iaoA-4y07A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 9 ILE A 591
LEU A 578
ARG A 606
ILE A 608
GLY A 609
 None
 1.37A 5ifuB-4y07A:
undetectable		 5ifuB-4y07A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 ILE A 608
VAL A 571
THR A 624
ILE A 622
 None
 0.72A 5mzrE-4y07A:
undetectable		 5mzrE-4y07A:
11.76