SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4y0b DOUBLE CLP-N MOTIF
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 VAL A 221
SER A 224
SER A 124
VAL A 135
LEU A 115
 None
 1.31A 1db1A-4y0bA:
undetectable		 1db1A-4y0bA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4y0b DOUBLE CLP-N MOTIF
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 SER A  93
THR A 164
VAL A 196
VAL A 126
VAL A 135
 None
 1.06A 2nniA-4y0bA:
undetectable		 2nniA-4y0bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4y0b DOUBLE CLP-N MOTIF
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 GLU A 222
SER A 181
VAL A 183
 None
 0.81A 3eeoA-4y0bA:
undetectable		 3eeoA-4y0bA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4y0b DOUBLE CLP-N MOTIF
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 VAL A 221
SER A 224
SER A 124
VAL A 135
LEU A 115
 None
 1.40A 3vt3A-4y0bA:
undetectable		 3vt3A-4y0bA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4y0b DOUBLE CLP-N MOTIF
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 VAL A 221
SER A 224
SER A 124
VAL A 135
LEU A 115
 None
 1.35A 3vt7A-4y0bA:
undetectable		 3vt7A-4y0bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4y0b DOUBLE CLP-N MOTIF
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 VAL A 126
GLY A 122
SER A  93
GLY A 117
 None
 0.79A 5e26C-4y0bA:
undetectable
5e26D-4y0bA:
undetectable		 5e26C-4y0bA:
21.85
5e26D-4y0bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4y0b DOUBLE CLP-N MOTIF
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ARG A 131
VAL A 135
LEU A 208
LEU A 193
LEU A 115
 None
 1.13A 6f6iA-4y0bA:
undetectable
6f6iB-4y0bA:
undetectable		 6f6iA-4y0bA:
21.94
6f6iB-4y0bA:
18.44