SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 7 ASP A 287
VAL A 197
GLY A 204
THR A 136
 None
 0.84A 1t7iB-4y0eA:
undetectable		 1t7iB-4y0eA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 7 ASP A 287
VAL A 197
GLY A 204
THR A 136
 None
 0.83A 1t7jB-4y0eA:
undetectable		 1t7jB-4y0eA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		3 / 3 ASP A 256
GLU A  44
TYR A  11
 MPD  A 402 (-3.5A)
None
None
 0.80A 1wsvA-4y0eA:
undetectable		 1wsvA-4y0eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		5 / 12 THR A 105
ASN A 257
TYR A 181
SER A 117
HIS A 262
 None
None
None
None
FE  A 401 (-3.2A)
 1.26A 2gl0A-4y0eA:
undetectable
2gl0C-4y0eA:
undetectable		 2gl0A-4y0eA:
18.64
2gl0C-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		5 / 12 THR A 105
ASN A 257
VAL A  86
SER A 117
HIS A 262
 None
None
None
None
FE  A 401 (-3.2A)
 1.11A 2gl0A-4y0eA:
undetectable
2gl0C-4y0eA:
undetectable		 2gl0A-4y0eA:
18.64
2gl0C-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A 104
SER A 117
THR A 105
ASN A 257
TYR A 181
 FE  A 401 ( 3.2A)
None
None
None
None
 1.38A 2gl0D-4y0eA:
undetectable
2gl0E-4y0eA:
undetectable		 2gl0D-4y0eA:
18.64
2gl0E-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A 104
SER A 117
THR A 105
ASN A 257
VAL A  86
 FE  A 401 ( 3.2A)
None
None
None
None
 1.42A 2gl0D-4y0eA:
undetectable
2gl0E-4y0eA:
undetectable		 2gl0D-4y0eA:
18.64
2gl0E-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		5 / 12 SER A 117
HIS A 262
THR A 105
ASN A 257
TYR A 181
 None
FE  A 401 (-3.2A)
None
None
None
 1.20A 2gl0D-4y0eA:
undetectable
2gl0E-4y0eA:
undetectable		 2gl0D-4y0eA:
18.64
2gl0E-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		5 / 12 SER A 117
HIS A 262
THR A 105
ASN A 257
VAL A  86
 None
FE  A 401 (-3.2A)
None
None
None
 1.10A 2gl0D-4y0eA:
undetectable
2gl0E-4y0eA:
undetectable		 2gl0D-4y0eA:
18.64
2gl0E-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 7 THR A  85
ALA A 100
PHE A 213
LEU A  96
 None
EPE  A 403 (-3.6A)
EPE  A 403 (-4.8A)
None
 1.02A 2hzqA-4y0eA:
undetectable		 2hzqA-4y0eA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 5 VAL A 284
GLN A 294
PHE A 109
ARG A 291
 None
 1.36A 3bjwE-4y0eA:
undetectable		 3bjwE-4y0eA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 5 VAL A 284
GLN A 294
PHE A 109
ARG A 291
 None
 1.35A 3bjwH-4y0eA:
undetectable		 3bjwH-4y0eA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		5 / 11 LEU A  38
LEU A  76
ARG A  47
GLY A  68
HIS A  63
 None
MPD  A 402 ( 4.1A)
MPD  A 402 (-4.3A)
None
None
 1.32A 3hm1B-4y0eA:
undetectable		 3hm1B-4y0eA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 5 ASN A 101
ALA A 266
ALA A  99
ARG A 273
 EPE  A 403 ( 4.6A)
None
None
None
 1.47A 3kp2B-4y0eA:
undetectable		 3kp2B-4y0eA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_A_HQEA200_1
(FLAVOREDOXIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 5 TYR A 303
VAL A 107
ARG A 198
HIS A 194
 None
EPE  A 403 (-4.2A)
None
None
 1.36A 3zofA-4y0eA:
0.0		 3zofA-4y0eA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		5 / 11 THR A 105
VAL A 110
ILE A 113
PHE A 213
LEU A 209
 None
None
None
EPE  A 403 (-4.8A)
None
 1.20A 4lhmA-4y0eA:
undetectable		 4lhmA-4y0eA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		3 / 3 ASP A 256
HIS A 200
LYS A 115
 MPD  A 402 (-3.5A)
MPD  A 402 (-4.5A)
MPD  A 402 (-3.3A)
 0.95A 4qzuD-4y0eA:
undetectable		 4qzuD-4y0eA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		3 / 3 GLU A 202
ILE A 254
ALA A 259
 MPD  A 402 (-2.9A)
None
None
 0.43A 4wnwB-4y0eA:
undetectable		 4wnwB-4y0eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 7 GLU A 307
ARG A 258
ASP A 256
ALA A 116
 None
None
MPD  A 402 (-3.5A)
MPD  A 402 ( 4.6A)
 1.13A 4zz8A-4y0eA:
undetectable		 4zz8A-4y0eA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		5 / 12 ILE A 254
ILE A  46
ALA A  71
VAL A 252
HIS A  63
 None
 1.16A 5km9B-4y0eA:
undetectable		 5km9B-4y0eA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		3 / 3 GLU A 205
HIS A 200
ARG A 198
 None
MPD  A 402 (-4.5A)
None
 0.76A 5uunA-4y0eA:
undetectable		 5uunA-4y0eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 5 HIS A 104
ASP A 106
HIS A 262
ARG A 277
 FE  A 401 ( 3.2A)
FE  A 401 ( 2.7A)
FE  A 401 (-3.2A)
EPE  A 403 ( 2.8A)
 0.42A 6dchA-4y0eA:
26.6		 6dchA-4y0eA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4y0e PUTATIVE DIOXYGENASE
(Mycobacteroides
abscessus) 		4 / 7 GLN A 233
GLY A 211
HIS A 104
VAL A 107
 None
None
FE  A 401 ( 3.2A)
EPE  A 403 (-4.2A)
 0.96A 6hu9S-4y0eA:
undetectable
6hu9q-4y0eA:
undetectable		 6hu9S-4y0eA:
14.95
6hu9q-4y0eA:
18.75