SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 9 GLU A 141
ILE A 182
ALA A 260
ILE A 147
THR A 199
 None
 1.40A 1aj6A-4y0iA:
undetectable		 1aj6A-4y0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 ILE A 182
ILE A 263
ALA A 218
LEU A 183
LEU A 284
 None
 1.07A 1bsxA-4y0iA:
undetectable		 1bsxA-4y0iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 ILE A 182
ILE A 263
ALA A 218
LEU A 183
LEU A 284
 None
 1.07A 1bsxB-4y0iA:
undetectable		 1bsxB-4y0iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 7 HIS A 190
LEU A 183
SER A 184
PHE A 295
 None
 1.07A 1ismB-4y0iA:
undetectable		 1ismB-4y0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 11 LEU A 284
ILE A 262
HIS A 190
PHE A 185
GLY A 187
 None
 1.25A 1zz1A-4y0iA:
4.2		 1zz1A-4y0iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 7 LEU A 461
PHE A 464
PHE A 460
LEU A 387
 None
 0.93A 2eikC-4y0iA:
undetectable
2eikJ-4y0iA:
undetectable		 2eikC-4y0iA:
19.27
2eikJ-4y0iA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 6 LEU A 461
PHE A 464
PHE A 460
LEU A 387
 None
 0.96A 3abkP-4y0iA:
undetectable
3abkW-4y0iA:
undetectable		 3abkP-4y0iA:
19.27
3abkW-4y0iA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 HIS A  81
VAL A 367
ILE A 371
LEU A 450
THR A 449
 None
 1.06A 3fw3B-4y0iA:
undetectable		 3fw3B-4y0iA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		3 / 3 ASP A 393
LEU A 394
GLN A 400
 None
 0.70A 3g4lA-4y0iA:
undetectable		 3g4lA-4y0iA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 5 HIS A 201
SER A 202
ASP A 298
THR A 199
 None
None
PSZ  A 501 (-2.8A)
None
 1.28A 3okxA-4y0iA:
undetectable		 3okxA-4y0iA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 5 HIS A 201
SER A 202
ASP A 298
THR A 199
 None
None
PSZ  A 501 (-2.8A)
None
 1.27A 3okxB-4y0iA:
undetectable		 3okxB-4y0iA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 GLY A 437
SER A 413
GLY A 440
LEU A  68
ASP A  67
 None
 1.39A 3r24A-4y0iA:
undetectable		 3r24A-4y0iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 6 LEU A 461
PHE A 464
PHE A 460
LEU A 387
 None
 0.96A 3wg7P-4y0iA:
undetectable
3wg7W-4y0iA:
undetectable		 3wg7P-4y0iA:
19.27
3wg7W-4y0iA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 7 LEU A 461
PHE A 464
PHE A 460
LEU A 387
 None
 0.95A 3x2qP-4y0iA:
undetectable
3x2qW-4y0iA:
undetectable		 3x2qP-4y0iA:
19.27
3x2qW-4y0iA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 5 ARG A 408
ILE A 267
HIS A 275
GLY A 407
 None
 1.19A 4e7cC-4y0iA:
undetectable		 4e7cC-4y0iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 ARG A 222
ALA A 218
ILE A 267
ARG A 406
GLY A 407
 None
 1.37A 4l9qA-4y0iA:
undetectable		 4l9qA-4y0iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 ARG A 222
ILE A 267
LEU A 223
ARG A 406
GLY A 407
 None
 1.02A 4l9qA-4y0iA:
undetectable		 4l9qA-4y0iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 GLY A 433
PRO A  16
LEU A  66
ASN A 431
LEU A 436
 None
 1.47A 5emlA-4y0iA:
3.0		 5emlA-4y0iA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		3 / 3 SER A  73
LEU A 364
MET A 332
 None
 0.86A 5ikrB-4y0iA:
undetectable		 5ikrB-4y0iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 5 LEU A 461
PHE A 464
PHE A 460
LEU A 387
 None
 0.97A 5x1bP-4y0iA:
undetectable		 5x1bP-4y0iA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 4 PHE A 280
ASP A 279
LEU A 284
LYS A 283
 None
 1.14A 6awvA-4y0iA:
undetectable		 6awvA-4y0iA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 5 PHE A 310
VAL A 297
MET A 331
VAL A 122
 None
 1.27A 6ekzA-4y0iA:
undetectable		 6ekzA-4y0iA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 4 LEU A 103
ASP A 357
PRO A 358
ARG A 100
 None
 1.30A 6fgdA-4y0iA:
undetectable		 6fgdA-4y0iA:
23.25