SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4y0m OXYR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 105
VAL A  95
GLY A  96
ALA A 143
LEU A 289
 None
 1.14A 1e7bA-4y0mA:
undetectable		 1e7bA-4y0mA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4y0m OXYR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 113
LEU A 122
ALA A 275
LEU A 160
ILE A 146
 None
 0.86A 2h42C-4y0mA:
undetectable		 2h42C-4y0mA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4y0m OXYR
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 160
ASP A 162
GLU A 163
ILE A 144
 None
 1.06A 4xi3C-4y0mA:
undetectable		 4xi3C-4y0mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4y0m OXYR
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  96
LYS A  94
ASP A 142
ASN A 127
 None
 1.01A 5mvsA-4y0mA:
undetectable		 5mvsA-4y0mA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4y0m OXYR
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 231
LEU A 243
PHE A 165
LEU A 227
 None
 1.29A 5xdxP-4y0mA:
undetectable
5xdxW-4y0mA:
undetectable		 5xdxP-4y0mA:
22.30
5xdxW-4y0mA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4y0m OXYR
(Pseudomonas
aeruginosa) 		4 / 6 THR A 129
PRO A 149
GLN A 203
ILE A 146
 None
 1.44A 6ef6A-4y0mA:
undetectable		 6ef6A-4y0mA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4y0m OXYR
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 161
VAL A 267
PRO A 244
VAL A 272
 None
 1.36A 6ekzA-4y0mA:
undetectable		 6ekzA-4y0mA:
17.62