SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 9 LEU A   5
ILE A  60
LEU A  40
GLY A  77
ALA A  83
 None
 1.21A 1e7aA-4y0wA:
undetectable		 1e7aA-4y0wA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 9 LEU A   5
ILE A  60
LEU A  40
GLY A  81
LEU A  54
 None
 1.21A 1e7aB-4y0wA:
undetectable		 1e7aB-4y0wA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 SER A  10
VAL A  72
GLY A  65
PRO A  66
PHE A  69
 NA  A 302 (-3.5A)
None
None
None
None
 1.47A 1fdsA-4y0wA:
2.3		 1fdsA-4y0wA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  63
VAL A  93
GLU A 141
SER A  10
ASP A   8
 None
None
None
NA  A 302 (-3.5A)
NA  A 302 (-3.6A)
 0.91A 1jdvE-4y0wA:
undetectable
1jdvF-4y0wA:
undetectable		 1jdvE-4y0wA:
21.43
1jdvF-4y0wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  63
VAL A  93
GLU A 141
SER A  10
ASP A   8
 None
None
None
NA  A 302 (-3.5A)
NA  A 302 (-3.6A)
 1.05A 1pk7C-4y0wA:
undetectable		 1pk7C-4y0wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  63
VAL A  93
GLU A 141
SER A  10
ASP A   8
 None
None
None
NA  A 302 (-3.5A)
NA  A 302 (-3.6A)
 0.99A 1pk9A-4y0wA:
undetectable		 1pk9A-4y0wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  63
VAL A  93
GLU A 141
SER A  10
ASP A   8
 None
None
None
NA  A 302 (-3.5A)
NA  A 302 (-3.6A)
 1.05A 1pk9C-4y0wA:
undetectable		 1pk9C-4y0wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 213
LEU A 211
VAL A  79
GLY A  77
ALA A  75
 None
 1.26A 1pxxD-4y0wA:
undetectable		 1pxxD-4y0wA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  75
LEU A  40
LEU A  54
ILE A  60
THR A   9
 None
 1.04A 1ra3A-4y0wA:
undetectable		 1ra3A-4y0wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  75
LEU A  40
LEU A  54
ILE A  60
THR A   9
 None
 0.97A 1rd7B-4y0wA:
undetectable		 1rd7B-4y0wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 10 ASP A   8
GLY A  63
GLY A  67
ILE A 116
ALA A  13
 NA  A 302 (-3.6A)
None
None
None
NA  A 302 (-4.1A)
 0.93A 1sh9B-4y0wA:
undetectable		 1sh9B-4y0wA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 211
ASP A  95
GLY A  71
ILE A  74
VAL A 213
 None
 0.87A 1t7jA-4y0wA:
undetectable		 1t7jA-4y0wA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 211
ASP A  95
GLY A  71
ILE A  74
VAL A 213
 None
 0.85A 2ieoB-4y0wA:
undetectable		 2ieoB-4y0wA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		4 / 5 TRP A 125
ALA A 114
LEU A 144
ALA A 115
 None
 1.35A 2jstA-4y0wA:
undetectable
2jstB-4y0wA:
undetectable		 2jstA-4y0wA:
14.22
2jstB-4y0wA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 211
ASP A  95
GLY A  71
ILE A  74
VAL A 213
 None
 0.71A 2nnkA-4y0wA:
undetectable		 2nnkA-4y0wA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 211
GLY A  63
GLY A  71
ILE A  74
VAL A 213
 None
 0.90A 2nnkA-4y0wA:
undetectable		 2nnkA-4y0wA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		3 / 3 SER A  26
ASP A   8
ASP A 190
 None
NA  A 302 (-3.6A)
None
 0.81A 2plwA-4y0wA:
undetectable		 2plwA-4y0wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		3 / 3 SER A  15
TYR A  28
HIS A  27
 None
 0.77A 2r2vD-4y0wA:
undetectable		 2r2vD-4y0wA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 10 PRO A 186
THR A  11
GLY A  67
LEU A 191
GLY A  63
 NA  A 302 ( 4.7A)
NA  A 302 (-3.2A)
None
None
None
 1.30A 2vl2A-4y0wA:
undetectable
2vl2C-4y0wA:
undetectable		 2vl2A-4y0wA:
25.53
2vl2C-4y0wA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  85
LEU A  47
LEU A   5
LEU A  82
LEU A  54
 None
 1.18A 2xn6A-4y0wA:
undetectable
2xn6B-4y0wA:
undetectable		 2xn6A-4y0wA:
23.16
2xn6B-4y0wA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 151
GLN A 129
ARG A 136
LEU A 194
 None
 1.05A 3bjwE-4y0wA:
undetectable		 3bjwE-4y0wA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		3 / 3 MET A 173
CYH A 127
PRO A 177
 None
 1.17A 3h52C-4y0wA:
undetectable		 3h52C-4y0wA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  95
SER A  10
SER A  15
LEU A 192
 None
NA  A 302 (-3.5A)
None
None
 1.02A 3m0wE-4y0wA:
undetectable
3m0wF-4y0wA:
undetectable
3m0wG-4y0wA:
undetectable
3m0wH-4y0wA:
undetectable		 3m0wE-4y0wA:
14.66
3m0wF-4y0wA:
14.66
3m0wG-4y0wA:
14.66
3m0wH-4y0wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 9 ASP A   8
GLY A  63
ILE A  74
GLY A  67
ILE A 116
 NA  A 302 (-3.6A)
None
None
None
None
 1.05A 3ogpB-4y0wA:
undetectable		 3ogpB-4y0wA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 211
ASP A  95
GLY A  71
ILE A  74
VAL A 213
 None
 0.87A 3u7sA-4y0wA:
undetectable		 3u7sA-4y0wA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  63
VAL A  93
GLU A 141
SER A  10
ASP A   8
 None
None
None
NA  A 302 (-3.5A)
NA  A 302 (-3.6A)
 0.95A 3uawA-4y0wA:
undetectable		 3uawA-4y0wA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 211
ASP A  95
GLY A  71
ILE A  74
VAL A 213
 None
 0.83A 3ucbA-4y0wA:
undetectable		 3ucbA-4y0wA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 211
GLY A  63
GLY A  71
ILE A  74
VAL A 213
 None
 0.98A 3ucbA-4y0wA:
undetectable		 3ucbA-4y0wA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 211
ASP A  95
GLY A  71
ILE A  74
VAL A 213
 None
 0.77A 3ucbB-4y0wA:
undetectable		 3ucbB-4y0wA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 211
GLY A  63
GLY A  71
ILE A  74
VAL A 213
 None
 0.90A 3ucbB-4y0wA:
undetectable		 3ucbB-4y0wA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 176
TRP A 167
GLY A 162
 None
 0.93A 4e7cA-4y0wA:
undetectable		 4e7cA-4y0wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 11 ALA A  75
LEU A  40
LEU A  54
ILE A  60
THR A   9
 None
 1.07A 4p66A-4y0wA:
undetectable		 4p66A-4y0wA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4y0w YEAZ
(Pseudomonas
aeruginosa) 		5 / 11 LEU A   7
GLY A  63
LEU A  39
ARG A  73
ALA A  75
 None
 1.03A 5o96G-4y0wA:
undetectable		 5o96G-4y0wA:
22.91