SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y13'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER
(Escherichia
coli) 		4 / 8 GLY A 118
THR A 120
LEU A  83
ASP A  80
 None
None
None
480  A 303 (-2.4A)
 0.79A 1aegA-4y13A:
undetectable		 1aegA-4y13A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER
(Escherichia
coli) 		4 / 5 GLY A 131
SER A 134
THR A 120
PHE A 132
 None
480  A 303 (-3.3A)
None
None
 1.29A 1icuC-4y13A:
undetectable
1icuD-4y13A:
undetectable		 1icuC-4y13A:
22.66
1icuD-4y13A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER
(Escherichia
coli) 		4 / 5 GLY A 131
SER A 134
THR A 120
PHE A 132
 None
480  A 303 (-3.3A)
None
None
 1.19A 1kqbA-4y13A:
undetectable
1kqbB-4y13A:
undetectable		 1kqbA-4y13A:
22.05
1kqbB-4y13A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER
(Escherichia
coli) 		5 / 12 ALA A 110
LEU A 106
ASN A  87
LEU A  93
TYR A  63
 GOL  A 304 (-2.8A)
480  A 303 ( 4.5A)
None
None
480  A 303 (-4.3A)
 1.20A 2w3mB-4y13A:
undetectable		 2w3mB-4y13A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER
(Escherichia
coli) 		5 / 12 ALA A 110
LEU A 106
ASN A  87
LEU A  93
TYR A  63
 GOL  A 304 (-2.8A)
480  A 303 ( 4.5A)
None
None
480  A 303 (-4.3A)
 1.35A 3eigA-4y13A:
undetectable		 3eigA-4y13A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER
(Escherichia
coli) 		4 / 5 LEU A 133
LYS A 153
GLN A 155
LEU A 157
 None
 0.69A 3h5gA-4y13A:
undetectable
3h5gB-4y13A:
undetectable		 3h5gA-4y13A:
7.82
3h5gB-4y13A:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER
(Escherichia
coli) 		5 / 12 TYR A  27
TYR A  42
LEU A 133
VAL A 158
SER A 161
 None
 1.44A 3vt7A-4y13A:
undetectable		 3vt7A-4y13A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER
(Escherichia
coli) 		4 / 5 ILE A 172
ILE A  30
TYR A  27
GLU A  31
 None
 0.97A 4a99D-4y13A:
undetectable		 4a99D-4y13A:
21.00