SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens) 		4 / 6 ASN A1742
ARG A1751
ILE A1707
GLY A1748
 None
 1.10A 1oniA-4y18A:
undetectable
1oniB-4y18A:
undetectable		 1oniA-4y18A:
18.39
1oniB-4y18A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens) 		4 / 6 ASN A1742
ARG A1751
ILE A1707
GLY A1748
 None
 1.10A 1oniD-4y18A:
undetectable
1oniF-4y18A:
undetectable		 1oniD-4y18A:
18.39
1oniF-4y18A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens) 		4 / 5 SER A1755
ARG A1751
PRO A1749
GLY A1748
 None
 1.48A 2y7kB-4y18A:
undetectable		 2y7kB-4y18A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens) 		3 / 3 THR A1675
SER A1651
PHE A1662
 None
 0.78A 3d4sA-4y18A:
undetectable		 3d4sA-4y18A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A1752
GLY A1709
GLY A1710
LEU A1780
ILE A1766
 None
 0.85A 3douA-4y18A:
undetectable		 3douA-4y18A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens) 		4 / 6 VAL A1833
SER A1841
ARG A1699
ILE A1707
 None
 0.97A 5jw1B-4y18A:
undetectable		 5jw1B-4y18A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens) 		3 / 3 THR A1834
PRO A1812
ASP A1813
 None
 0.91A 5l8dB-4y18A:
undetectable		 5l8dB-4y18A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens) 		3 / 3 THR A1834
PRO A1812
ASP A1813
 None
 0.91A 5mwuB-4y18A:
undetectable		 5mwuB-4y18A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens) 		3 / 3 GLU A1731
HIS A1732
ARG A1753
 None
 0.82A 5uunA-4y18A:
undetectable		 5uunA-4y18A:
20.60