SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		5 / 12 LEU A 119
ALA A 184
ALA A 187
ALA A 185
GLN A 142
 None
 1.14A 1rbpA-4y1bA:
undetectable		 1rbpA-4y1bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		4 / 4 SER A 216
ILE A 219
VAL A 233
THR A 306
 None
None
NAP  A 501 (-3.9A)
NAP  A 501 (-3.9A)
 1.04A 1u70A-4y1bA:
2.2		 1u70A-4y1bA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		3 / 3 ASP A 203
ARG A 200
ASP A 315
 None
 0.80A 1vptA-4y1bA:
4.6		 1vptA-4y1bA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		3 / 3 VAL A 232
VAL A 230
TRP A 208
 None
None
NAP  A 501 ( 4.8A)
 0.97A 1w5uC-4y1bA:
undetectable
1w5uD-4y1bA:
undetectable		 1w5uC-4y1bA:
4.78
1w5uD-4y1bA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		4 / 7 TYR A 147
ASN A  66
HIS A  91
VAL A 144
 None
 1.42A 1wu8A-4y1bA:
undetectable
1wu8C-4y1bA:
undetectable		 1wu8A-4y1bA:
19.10
1wu8C-4y1bA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		3 / 3 VAL A 230
TRP A 208
VAL A 232
 None
NAP  A 501 ( 4.8A)
None
 0.96A 2izqA-4y1bA:
undetectable
2izqB-4y1bA:
undetectable		 2izqA-4y1bA:
4.78
2izqB-4y1bA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		5 / 12 GLY A  61
ILE A  92
GLY A 146
VAL A  55
VAL A  57
 None
 0.61A 2nnkA-4y1bA:
undetectable		 2nnkA-4y1bA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		5 / 12 GLY A  61
ILE A  92
GLY A 146
VAL A  55
VAL A  57
 None
 0.81A 2nnkB-4y1bA:
undetectable		 2nnkB-4y1bA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		4 / 6 TRP A 259
GLY A 209
GLY A 303
PHE A 281
 None
NAP  A 501 (-2.9A)
None
None
 0.90A 2qx6A-4y1bA:
3.8
2qx6B-4y1bA:
3.7		 2qx6A-4y1bA:
21.44
2qx6B-4y1bA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		5 / 10 SER A 173
ALA A 175
ALA A 404
ALA A  59
SER A  98
 None
 1.41A 2r2vC-4y1bA:
undetectable
2r2vF-4y1bA:
undetectable
2r2vG-4y1bA:
undetectable		 2r2vC-4y1bA:
8.01
2r2vF-4y1bA:
8.01
2r2vG-4y1bA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		4 / 7 GLY A  94
ALA A 158
ALA A 155
VAL A 160
 None
 0.81A 3a2qA-4y1bA:
undetectable		 3a2qA-4y1bA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		5 / 12 VAL A 298
GLU A 300
SER A 310
PHE A 281
GLY A 209
 None
None
None
None
NAP  A 501 (-2.9A)
 1.29A 3j6pB-4y1bA:
2.7		 3j6pB-4y1bA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		3 / 3 VAL A 232
VAL A 230
TRP A 208
 None
None
NAP  A 501 ( 4.8A)
 0.90A 3l8lA-4y1bA:
undetectable
3l8lB-4y1bA:
undetectable		 3l8lA-4y1bA:
4.78
3l8lB-4y1bA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		3 / 3 VAL A 232
VAL A 230
TRP A 208
 None
None
NAP  A 501 ( 4.8A)
 0.92A 3l8lC-4y1bA:
undetectable
3l8lD-4y1bA:
undetectable		 3l8lC-4y1bA:
4.78
3l8lD-4y1bA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		4 / 5 PHE A  38
ILE A  26
GLY A  94
HIS A 385
 None
 1.06A 3r0lD-4y1bA:
undetectable		 3r0lD-4y1bA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		5 / 12 PHE A 281
PHE A 285
PRO A 295
VAL A 222
ALA A 231
 None
 1.25A 4a84A-4y1bA:
undetectable		 4a84A-4y1bA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		3 / 3 TRP A 123
GLN A 128
THR A 141
 None
 0.88A 4m2xA-4y1bA:
2.6		 4m2xA-4y1bA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		4 / 4 TYR A  64
THR A 326
GLY A 324
LEU A 214
 NAP  A 501 (-3.2A)
NAP  A 501 (-3.6A)
NAP  A 501 ( 3.3A)
NAP  A 501 (-3.8A)
 1.16A 4w5nA-4y1bA:
undetectable		 4w5nA-4y1bA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		4 / 5 GLY A 328
GLU A 300
HIS A 301
ASP A 305
 None
None
NAP  A 501 (-3.2A)
NAP  A 501 (-3.2A)
 1.06A 5c0oH-4y1bA:
6.6		 5c0oH-4y1bA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		5 / 12 VAL A 298
GLU A 300
SER A 310
PHE A 281
GLY A 209
 None
None
None
None
NAP  A 501 (-2.9A)
 1.24A 5ogcB-4y1bA:
2.8		 5ogcB-4y1bA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		4 / 5 PRO A 201
VAL A 225
GLY A 249
VAL A 205
 None
 1.11A 6ak3B-4y1bA:
undetectable		 6ak3B-4y1bA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		3 / 3 TRP A 250
ILE A 251
ASP A 252
 None
 0.86A 6i0y7-4y1bA:
undetectable		 6i0y7-4y1bA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4y1b ANTE
(Streptomyces
sp.
NRRL
2288) 		5 / 12 VAL A 400
ASP A 390
PHE A  38
PHE A 154
VAL A  35
 None
 1.45A 6iblA-4y1bA:
undetectable		 6iblA-4y1bA:
24.10