SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		4 / 4 THR A 156
LEU A 157
LEU A  52
GLN A  48
 None
 1.17A 1fbmA-4y1kA:
undetectable		 1fbmA-4y1kA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		4 / 5 THR A 378
LEU A 373
GLY A  25
TYR A  24
 None
 1.38A 1gtiF-4y1kA:
undetectable		 1gtiF-4y1kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 256
SER A 160
LEU A 257
TYR A 165
THR A 163
 None
 1.49A 2idkA-4y1kA:
undetectable
2idkB-4y1kA:
1.6
2idkC-4y1kA:
0.0
2idkD-4y1kA:
0.0		 2idkA-4y1kA:
21.23
2idkB-4y1kA:
21.23
2idkC-4y1kA:
21.23
2idkD-4y1kA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 275
LEU A 446
TYR A  18
ALA A  12
ASP A  37
 None
 1.32A 2iyfB-4y1kA:
undetectable		 2iyfB-4y1kA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 394
TYR A 397
LYS A 402
 None
 1.12A 2othA-4y1kA:
undetectable		 2othA-4y1kA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  43
GLY A 447
GLY A 449
ALA A 159
ASP A  37
 None
 1.06A 2zulA-4y1kA:
undetectable		 2zulA-4y1kA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  43
GLY A 447
GLY A 449
ALA A 159
ASP A  37
 None
 1.08A 3dmfA-4y1kA:
undetectable		 3dmfA-4y1kA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  43
GLY A 447
GLY A 449
ALA A 159
ASP A  37
 None
 1.05A 3dmhA-4y1kA:
undetectable		 3dmhA-4y1kA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 275
ILE A 362
TYR A  18
PRO A  19
VAL A 369
 None
 1.36A 3elzB-4y1kA:
undetectable		 3elzB-4y1kA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 190
ARG A 194
ARG A 217
 None
 0.81A 3k37A-4y1kA:
undetectable		 3k37A-4y1kA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 447
ALA A  36
SER A 266
TYR A  18
GLU A 368
 None
 1.42A 4bupA-4y1kA:
undetectable		 4bupA-4y1kA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  78
GLU A 147
TYR A  77
 None
 0.96A 4r29D-4y1kA:
1.1		 4r29D-4y1kA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		4 / 8 SER A 104
THR A 106
ARG A  98
ILE A 111
 None
 0.91A 5jhdE-4y1kA:
undetectable
5jhdG-4y1kA:
undetectable		 5jhdE-4y1kA:
21.33
5jhdG-4y1kA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  52
GLY A  54
LEU A 234
LEU A 237
VAL A 161
 None
 0.93A 5twjA-4y1kA:
undetectable		 5twjA-4y1kA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  52
GLY A  54
LEU A 234
LEU A 237
VAL A 161
 None
 0.94A 5twjB-4y1kA:
undetectable		 5twjB-4y1kA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  52
GLY A  54
LEU A 234
LEU A 237
VAL A 161
 None
 0.90A 5twjC-4y1kA:
undetectable		 5twjC-4y1kA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 379
SER A 438
ALA A 370
ALA A 374
GLY A 372
 None
 1.15A 5tzoA-4y1kA:
undetectable		 5tzoA-4y1kA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 379
SER A 438
ALA A 370
ALA A 374
GLY A 372
 None
 1.19A 5tzoC-4y1kA:
undetectable		 5tzoC-4y1kA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4y1k OUTER MEMBRANE
PROTEIN OPRM
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 239
SER A 240
LEU A  52
VAL A  55
LEU A 168
 None
 1.10A 5w7pA-4y1kA:
undetectable		 5w7pA-4y1kA:
23.29