SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		4 / 5 VAL A 218
CYH A 167
ALA A 182
CYH A 185
 None
 1.19A 1mz9D-4y1pA:
undetectable		 1mz9D-4y1pA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 11 ILE A 332
ALA A 331
VAL A 308
VAL A 319
LEU A 276
 None
 1.22A 1n4hA-4y1pA:
undetectable		 1n4hA-4y1pA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		3 / 3 ARG A 117
ARG A  96
ILE A 217
 IPM  A 402 (-2.8A)
IPM  A 402 (-2.9A)
None
 0.79A 1uobA-4y1pA:
undetectable		 1uobA-4y1pA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 315
ALA A 304
ILE A 305
ILE A 332
ALA A 331
 None
 1.09A 2bxcA-4y1pA:
undetectable		 2bxcA-4y1pA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		3 / 3 SER A 228
GLU A 254
ASP A 225
 None
IPM  A 402 ( 4.5A)
MG  A 401 ( 2.7A)
 0.63A 2zthA-4y1pA:
undetectable		 2zthA-4y1pA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		4 / 6 GLY A 232
ILE A 234
ILE A 113
ASP A 229
 None
None
None
MG  A 401 (-4.0A)
 0.80A 3a7eA-4y1pA:
undetectable		 3a7eA-4y1pA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		3 / 3 SER A 228
GLU A 254
ASP A 225
 None
IPM  A 402 ( 4.5A)
MG  A 401 ( 2.7A)
 0.61A 3bwmA-4y1pA:
undetectable		 3bwmA-4y1pA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		3 / 3 SER A 228
GLU A 254
ASP A 225
 None
IPM  A 402 ( 4.5A)
MG  A 401 ( 2.7A)
 0.63A 3bwyA-4y1pA:
undetectable		 3bwyA-4y1pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A 312
SER A 323
THR A 316
SER A 330
ALA A 331
 None
 1.20A 3d91A-4y1pA:
undetectable		 3d91A-4y1pA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 282
ASN A 296
LEU A 301
LEU A  34
ARG A 293
 None
None
None
None
SO4  A 403 (-4.4A)
 1.39A 3fsuA-4y1pA:
undetectable		 3fsuA-4y1pA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A  44
GLY A  12
GLY A  14
ASP A  45
VAL A  82
 None
 1.12A 4b17A-4y1pA:
undetectable		 4b17A-4y1pA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A  55
GLN A   9
ILE A   8
ILE A  63
ALA A  66
 None
 0.90A 4ltwA-4y1pA:
undetectable		 4ltwA-4y1pA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		4 / 6 ASP A  45
VAL A  81
ALA A 259
PHE A 261
 None
 1.11A 4nedA-4y1pA:
undetectable		 4nedA-4y1pA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 9 ALA A  98
ALA A 235
LEU A 101
SER A 243
VAL A 256
 None
 1.37A 4or0A-4y1pA:
undetectable		 4or0A-4y1pA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		3 / 3 SER A 228
GLU A 254
ASP A 225
 None
IPM  A 402 ( 4.5A)
MG  A 401 ( 2.7A)
 0.60A 4xudA-4y1pA:
undetectable		 4xudA-4y1pA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		4 / 6 LEU A 315
TYR A 314
LYS A 313
GLU A 311
 None
 1.27A 4z4gA-4y1pA:
2.3		 4z4gA-4y1pA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 9 LEU A 315
MET A 328
VAL A 308
LEU A 275
ILE A 332
 None
 1.03A 6fdyU-4y1pA:
undetectable		 6fdyU-4y1pA:
23.05