SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MDA_A_RLTA403_1 (MARINER MOS1 TRANSPOSASE)	4y1t	PERFORIN-1 (Mus musculus)	4 / 6	ASP A 429 ASP A 485 ALA A 488 ASP A 435	CA A 601 (-2.2A) CA A 604 ( 2.3A) None CA A 603 ( 2.3A)	1.15A	4mdaA-4y1tA: undetectable	4mdaA-4y1tA: 17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MDB_A_RLTA401_1 (MARINER MOS1 TRANSPOSASE)	4y1t	PERFORIN-1 (Mus musculus)	4 / 6	ASP A 429 ASP A 485 ALA A 488 ASP A 435	CA A 601 (-2.2A) CA A 604 ( 2.3A) None CA A 603 ( 2.3A)	1.11A	4mdbA-4y1tA: undetectable	4mdbA-4y1tA: 17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E72_A_SAMA400_1 (N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE)	4y1t	PERFORIN-1 (Mus musculus)	4 / 4	ASP A 435 GLY A 428 ASP A 491 ASP A 489	CA A 603 ( 2.3A) CA A 604 (-4.5A) CA A 602 ( 2.7A) None	1.14A	5e72A-4y1tA: undetectable	5e72A-4y1tA: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GTQ_A_ACTA204_0 (N-ACETYLTRANSFERASE)	4y1t	PERFORIN-1 (Mus musculus)	4 / 5	LEU A 534 THR A 532 THR A 529 GLY A 530	None	1.12A	6gtqA-4y1tA: undetectable	6gtqA-4y1tA: 20.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4MDA_A_RLTA403_1","MARINER MOS1 TRANSPOSASE","4y1t","PERFORIN-1","Mus musculus",4,"ASP A 429;ASP A 485;ALA A 488;ASP A 435"," CA A 601 (-2.2A); CA A 604 ( 2.3A);None; CA A 603 ( 2.3A)","1.15A","4mdaA-4y1tA:undetectable","4mdaA-4y1tA:17.70"],["4MDB_A_RLTA401_1","MARINER MOS1 TRANSPOSASE","4y1t","PERFORIN-1","Mus musculus",4,"ASP A 429;ASP A 485;ALA A 488;ASP A 435"," CA A 601 (-2.2A); CA A 604 ( 2.3A);None; CA A 603 ( 2.3A)","1.11A","4mdbA-4y1tA:undetectable","4mdbA-4y1tA:17.70"],["5E72_A_SAMA400_1","N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","4y1t","PERFORIN-1","Mus musculus",4,"ASP A 435;GLY A 428;ASP A 491;ASP A 489"," CA A 603 ( 2.3A); CA A 604 (-4.5A); CA A 602 ( 2.7A);None","1.14A","5e72A-4y1tA:undetectable","5e72A-4y1tA:20.63"],["6GTQ_A_ACTA204_0","N-ACETYLTRANSFERASE","4y1t","PERFORIN-1","Mus musculus",4,"LEU A 534;THR A 532;THR A 529;GLY A 530","None","1.12A","6gtqA-4y1tA:undetectable","6gtqA-4y1tA:20.41"]]