SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4y1y GALECTIN-1
(Homo
sapiens) 		3 / 3 ASP A  26
PHE A  49
VAL A  23
 None
 0.78A 1kijB-4y1yA:
undetectable		 1kijB-4y1yA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4y1y GALECTIN-1
(Homo
sapiens) 		4 / 8 ASN A  33
LYS A  43
PRO A  47
PHE A  79
 None
CSO  A  42 ( 3.6A)
None
None
 1.41A 3bjwD-4y1yA:
undetectable		 3bjwD-4y1yA:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4y1y GALECTIN-1
(Homo
sapiens) 		6 / 6 HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
 0.49A 3galA-4y1yA:
20.0		 3galA-4y1yA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4y1y GALECTIN-1
(Homo
sapiens) 		6 / 6 HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
 0.41A 3galB-4y1yA:
19.6		 3galB-4y1yA:
33.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4y1y GALECTIN-1
(Homo
sapiens) 		5 / 11 VAL A  98
PHE A 106
PHE A  30
LEU A 100
PHE A  79
 CSO  A  88 ( 4.1A)
CSO  A  60 ( 3.8A)
None
None
None
 1.05A 3t3rA-4y1yA:
undetectable		 3t3rA-4y1yA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4y1y GALECTIN-1
(Homo
sapiens) 		5 / 9 ALA A 121
LEU A  17
LEU A  34
ASN A  46
ILE A  89
 None
CSO  A  16 ( 4.5A)
None
GAL  A 201 (-4.4A)
CSO  A  88 ( 3.8A)
 1.14A 3wdmC-4y1yA:
undetectable		 3wdmC-4y1yA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4y1y GALECTIN-1
(Homo
sapiens) 		4 / 8 SER A  38
ASN A  33
GLY A  35
GLY A  65
 None
None
CSO  A  42 ( 3.8A)
None
 0.86A 4fo4B-4y1yA:
undetectable		 4fo4B-4y1yA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4y1y GALECTIN-1
(Homo
sapiens) 		5 / 12 PHE A  30
ALA A 122
PHE A  77
LEU A 100
PHE A 106
 None
None
None
None
CSO  A  60 ( 3.8A)
 1.28A 4kykA-4y1yA:
undetectable
4kykB-4y1yA:
undetectable		 4kykA-4y1yA:
22.55
4kykB-4y1yA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4y1y GALECTIN-1
(Homo
sapiens) 		4 / 5 LEU A   4
VAL A  87
VAL A  23
ARG A  73
 None
CSO  A  88 ( 3.1A)
None
6S2  A 202 (-3.8A)
 1.10A 4r7iA-4y1yA:
undetectable		 4r7iA-4y1yA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4y1y GALECTIN-1
(Homo
sapiens) 		7 / 7 HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
6S2  A 202 (-3.8A)
 0.44A 6b8kA-4y1yA:
19.5		 6b8kA-4y1yA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 4y1y GALECTIN-1
(Homo
sapiens) 		8 / 8 HIS A  44
ASN A  46
ARG A  48
HIS A  52
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-4.2A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
6S2  A 202 (-3.8A)
 0.36A 6b94A-4y1yA:
28.7		 6b94A-4y1yA:
78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 4y1y GALECTIN-1
(Homo
sapiens) 		9 / 10 HIS A  44
ASN A  46
ARG A  48
HIS A  52
ASP A  54
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-4.2A)
6S2  A 202 (-3.5A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
6S2  A 202 (-3.8A)
 0.44A 6b94A-4y1yA:
28.7
6b94B-4y1yA:
26.8		 6b94A-4y1yA:
78.79
6b94B-4y1yA:
78.79