SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 4 THR A  58
LEU A  54
VAL A  51
LEU A  47
 None
 0.93A 1mz9D-4y21A:
undetectable		 1mz9D-4y21A:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 LEU A 277
ALA A 303
VAL A 273
LEU A 343
GLN A 346
 None
 1.18A 1rbpA-4y21A:
undetectable		 1rbpA-4y21A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 10 LEU A 277
VAL A 273
LEU A 343
GLN A 346
PHE A 302
 None
 1.23A 1rlbE-4y21A:
undetectable		 1rlbE-4y21A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 7 LEU A 277
PHE A 274
ARG A 344
LEU A 367
 None
 1.08A 2eikA-4y21A:
undetectable
2eikJ-4y21A:
undetectable		 2eikA-4y21A:
21.36
2eikJ-4y21A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 8 PHE A 281
ILE A 284
GLY A 296
ILE A 294
 None
 0.81A 2qwxA-4y21A:
undetectable
2qwxB-4y21A:
undetectable		 2qwxA-4y21A:
17.75
2qwxB-4y21A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A  85
TRP A 169
TYR A  89
 None
 0.89A 3aicA-4y21A:
undetectable		 3aicA-4y21A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A  85
TRP A 169
TYR A  89
 None
 0.85A 3aicB-4y21A:
undetectable		 3aicB-4y21A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A  85
TRP A 169
TYR A  89
 None
 0.88A 3aicE-4y21A:
undetectable		 3aicE-4y21A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A  85
TRP A 169
TYR A  89
 None
 0.98A 3aicF-4y21A:
undetectable		 3aicF-4y21A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A  85
TRP A 169
TYR A  89
 None
 0.88A 3aicG-4y21A:
undetectable		 3aicG-4y21A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A  85
TRP A 169
TYR A  89
 None
 0.85A 3aicH-4y21A:
undetectable		 3aicH-4y21A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 11 LEU A 277
ALA A 303
VAL A 273
LEU A 343
GLN A 346
 None
 1.19A 3bszE-4y21A:
undetectable		 3bszE-4y21A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 6 VAL A 230
LEU A 188
ILE A 294
ILE A 231
 None
 0.61A 3gcsA-4y21A:
undetectable		 3gcsA-4y21A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 6 LEU A 404
ALA A 498
THR A 543
THR A 540
 None
 0.97A 3mdrA-4y21A:
undetectable		 3mdrA-4y21A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 8 TYR A 100
TYR A 104
LEU A 204
TRP A 203
 None
 1.17A 3uzzB-4y21A:
undetectable		 3uzzB-4y21A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 ILE A 163
THR A  88
PHE A 172
LEU A 171
TYR A  32
 None
 1.23A 4cd2A-4y21A:
undetectable		 4cd2A-4y21A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 5 LYS A 216
LEU A 212
GLU A 211
LYS A 162
 None
 1.23A 4k4yA-4y21A:
undetectable		 4k4yA-4y21A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 9 THR A 366
LEU A 367
ALA A 303
LEU A 277
LEU A 359
 None
 1.41A 4ltwA-4y21A:
undetectable		 4ltwA-4y21A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 SER A 164
MET A 168
ASP A  79
 None
 0.88A 4mm4B-4y21A:
undetectable		 4mm4B-4y21A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 ILE A 507
ALA A 503
LEU A 429
ALA A 425
LEU A 529
 None
 1.15A 4nqaH-4y21A:
undetectable		 4nqaH-4y21A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 8 PHE A 281
ILE A 284
GLY A 296
ILE A 294
 None
 0.85A 4qogA-4y21A:
undetectable
4qogB-4y21A:
undetectable		 4qogA-4y21A:
17.75
4qogB-4y21A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 LEU A 249
VAL A 270
SER A 267
VAL A 332
SER A 323
 None
 1.42A 5v1tA-4y21A:
undetectable		 5v1tA-4y21A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 11 VAL A 332
ASP A 252
LEU A 336
ASN A 338
ASN A 339
 None
 1.02A 5x6yA-4y21A:
undetectable		 5x6yA-4y21A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 11 VAL A 332
ASP A 252
LEU A 336
ASN A 338
ASN A 339
 None
 1.01A 5x6yC-4y21A:
undetectable		 5x6yC-4y21A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 8 LEU A 277
PHE A 274
ARG A 344
LEU A 367
 None
 0.87A 5zcqN-4y21A:
undetectable
5zcqW-4y21A:
undetectable		 5zcqN-4y21A:
21.36
5zcqW-4y21A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 VAL A 500
LEU A 504
PHE A 511
ALA A 535
LEU A 536
 None
 0.89A 6ajiA-4y21A:
2.1		 6ajiA-4y21A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4y21 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 4 LEU A 429
ASP A 426
GLN A 430
VAL A 455
 None
 1.36A 6bzoF-4y21A:
3.2		 6bzoF-4y21A:
22.04