SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 8 ARG A 511
TYR A 317
GLU A 523
SER A 569
 None
 1.11A 1nx9B-4y23A:
undetectable		 1nx9B-4y23A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 8 ARG A 511
TYR A 317
GLU A 523
SER A 569
 None
 1.12A 1nx9D-4y23A:
undetectable		 1nx9D-4y23A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 LEU A 435
ILE A  87
PHE A 236
ILE A 245
TYR A 237
 None
 1.04A 1osvB-4y23A:
undetectable		 1osvB-4y23A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 LEU A 435
ILE A  87
PHE A 236
ILE A 245
TYR A 237
 None
 1.03A 1ot7B-4y23A:
undetectable		 1ot7B-4y23A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 8 PHE A 490
LEU A 298
ASP A 302
THR A 492
 None
 1.02A 1rmtD-4y23A:
undetectable		 1rmtD-4y23A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 7 TYR A 237
GLU A 438
THR A 416
SER A 108
 None
NA  A 601 (-4.4A)
None
None
 1.19A 1tv8A-4y23A:
undetectable		 1tv8A-4y23A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 GLU A 110
SER A 108
VAL A 249
ASN A 436
VAL A 141
 None
 1.41A 1x70A-4y23A:
undetectable		 1x70A-4y23A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 GLU A 110
SER A 108
VAL A 249
ASN A 436
VAL A 141
 None
 1.45A 1x70B-4y23A:
undetectable		 1x70B-4y23A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 LEU A 435
PRO A 429
VAL A 428
ILE A 426
 None
 0.93A 2aoiB-4y23A:
undetectable		 2aoiB-4y23A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 10 TYR A 431
ILE A 245
ALA A 244
ILE A 228
ILE A  87
 None
 1.25A 2dm6A-4y23A:
undetectable
2dm6B-4y23A:
undetectable		 2dm6A-4y23A:
21.27
2dm6B-4y23A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.21A 2f162-4y23A:
undetectable		 2f162-4y23A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.21A 2f16N-4y23A:
undetectable		 2f16N-4y23A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 LEU A  60
ALA A  69
ILE A  73
THR A  47
ILE A 466
 None
 1.17A 2jn3A-4y23A:
undetectable		 2jn3A-4y23A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		3 / 3 ASP A 303
PHE A 304
LEU A 306
 None
 0.73A 2zi9A-4y23A:
undetectable		 2zi9A-4y23A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 LEU A 435
GLY A 138
PRO A 429
VAL A 428
ILE A 426
 None
 0.84A 3cywA-4y23A:
undetectable		 3cywA-4y23A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 PRO A 429
VAL A 248
THR A 146
GLY A  89
 None
 1.20A 3elzB-4y23A:
1.5		 3elzB-4y23A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 9 LEU A 150
PRO A 168
SER A 169
VAL A  59
GLY A  56
 None
 1.37A 3hcnB-4y23A:
undetectable		 3hcnB-4y23A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 THR A 417
THR A 416
THR A 415
ALA A 399
SER A 460
 NA  A 601 ( 4.7A)
None
None
None
NA  A 601 ( 4.4A)
 0.88A 3mg02-4y23A:
undetectable
3mg0V-4y23A:
2.1		 3mg02-4y23A:
16.70
3mg0V-4y23A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.21A 3mg0N-4y23A:
undetectable		 3mg0N-4y23A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 10 VAL A 249
GLY A  88
ILE A  87
ALA A 244
VAL A 248
 None
 1.02A 3t3cB-4y23A:
undetectable		 3t3cB-4y23A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 10 ILE A 228
TYR A 431
ILE A 241
ALA A 235
GLU A 240
 None
 1.24A 3u6tA-4y23A:
undetectable		 3u6tA-4y23A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 LEU A  60
GLY A  64
THR A 159
ILE A  71
 None
 0.90A 3wriA-4y23A:
undetectable		 3wriA-4y23A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 LEU A  60
GLY A  64
THR A 159
ILE A  71
 None
 0.91A 3wriB-4y23A:
2.0		 3wriB-4y23A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 HIS A 277
LEU A 349
LEU A 300
ASP A 350
 None
 1.20A 4aqlA-4y23A:
undetectable		 4aqlA-4y23A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 7 LEU A  60
THR A 405
ILE A 554
GLY A  40
 None
 0.90A 4eqlB-4y23A:
undetectable		 4eqlB-4y23A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 PHE A 203
THR A 173
PHE A 177
ILE A 202
 None
 1.19A 4jx1E-4y23A:
undetectable		 4jx1E-4y23A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 7 LEU A  60
THR A 405
ILE A 554
GLY A  40
 None
 0.90A 4l39B-4y23A:
undetectable		 4l39B-4y23A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_2
(ANDROGEN RECEPTOR)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 4 ASN A 550
MET A  83
LEU A  77
HIS A  49
 None
 1.41A 4oktA-4y23A:
0.0		 4oktA-4y23A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 ALA A 399
THR A 400
GLY A  89
GLY A  90
SER A 460
 None
None
None
None
NA  A 601 ( 4.4A)
 0.97A 4qvlK-4y23A:
2.8
4qvlL-4y23A:
3.3		 4qvlK-4y23A:
18.69
4qvlL-4y23A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 ALA A 399
THR A 400
GLY A  89
GLY A  90
SER A 460
 None
None
None
None
NA  A 601 ( 4.4A)
 0.96A 4qvlY-4y23A:
undetectable
4qvlZ-4y23A:
undetectable		 4qvlY-4y23A:
18.69
4qvlZ-4y23A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 10 ALA A 399
THR A 400
GLY A  89
GLY A  90
SER A 460
 None
None
None
None
NA  A 601 ( 4.4A)
 0.98A 4qvmY-4y23A:
2.8
4qvmZ-4y23A:
undetectable		 4qvmY-4y23A:
18.69
4qvmZ-4y23A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 SER A 460
THR A 417
THR A 416
THR A 415
ALA A 399
 NA  A 601 ( 4.4A)
NA  A 601 ( 4.7A)
None
None
None
 0.86A 4qvnV-4y23A:
undetectable
4qvnb-4y23A:
undetectable		 4qvnV-4y23A:
17.44
4qvnb-4y23A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.18A 4qvnV-4y23A:
undetectable
4qvnb-4y23A:
undetectable		 4qvnV-4y23A:
17.44
4qvnb-4y23A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 SER A 460
THR A 417
THR A 416
THR A 415
ALA A 399
 NA  A 601 ( 4.4A)
NA  A 601 ( 4.7A)
None
None
None
 0.84A 4qvnH-4y23A:
undetectable
4qvnN-4y23A:
undetectable		 4qvnH-4y23A:
17.44
4qvnN-4y23A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.18A 4qvnH-4y23A:
undetectable
4qvnN-4y23A:
undetectable		 4qvnH-4y23A:
17.44
4qvnN-4y23A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 ALA A 399
THR A 400
GLY A  89
GLY A  90
SER A 460
 None
None
None
None
NA  A 601 ( 4.4A)
 0.99A 4qvwK-4y23A:
2.7
4qvwL-4y23A:
undetectable		 4qvwK-4y23A:
18.69
4qvwL-4y23A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 ALA A 399
THR A 400
GLY A  90
GLY A  91
SER A 460
 None
None
None
None
NA  A 601 ( 4.4A)
 1.12A 4qvwK-4y23A:
2.7
4qvwL-4y23A:
undetectable		 4qvwK-4y23A:
18.69
4qvwL-4y23A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 ALA A 399
THR A 400
GLY A  89
GLY A  90
SER A 460
 None
None
None
None
NA  A 601 ( 4.4A)
 0.99A 4qvwY-4y23A:
undetectable
4qvwZ-4y23A:
3.3		 4qvwY-4y23A:
18.69
4qvwZ-4y23A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 ALA A 399
THR A 400
GLY A  89
GLY A  90
SER A 460
 None
None
None
None
NA  A 601 ( 4.4A)
 0.97A 4qw1K-4y23A:
2.7
4qw1L-4y23A:
3.4		 4qw1K-4y23A:
18.87
4qw1L-4y23A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 6 SER A 362
LEU A 363
ASP A 364
LEU A 319
 None
 1.01A 4wozA-4y23A:
undetectable
4wozB-4y23A:
undetectable		 4wozA-4y23A:
20.61
4wozB-4y23A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 9 ILE A 228
TYR A 431
ILE A 241
ALA A 235
GLU A 240
 None
 1.17A 4yp2B-4y23A:
undetectable		 4yp2B-4y23A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 ALA A 399
THR A 400
GLY A  89
GLY A  90
SER A 460
 None
None
None
None
NA  A 601 ( 4.4A)
 0.98A 5bxnK-4y23A:
2.8
5bxnL-4y23A:
undetectable		 5bxnK-4y23A:
18.69
5bxnL-4y23A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 11 ALA A 399
THR A 400
GLY A  89
GLY A  90
SER A 460
 None
None
None
None
NA  A 601 ( 4.4A)
 0.96A 5bxnY-4y23A:
undetectable
5bxnZ-4y23A:
undetectable		 5bxnY-4y23A:
18.69
5bxnZ-4y23A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 8 LEU A 421
GLU A  81
LEU A 183
LEU A 194
 None
 0.77A 5dxeA-4y23A:
undetectable		 5dxeA-4y23A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 7 ASN A 572
SER A 181
ALA A 184
GLY A 213
 None
 0.90A 5fpdA-4y23A:
undetectable		 5fpdA-4y23A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 6 ILE A 281
TYR A 276
PHE A 490
THR A 323
 None
 1.26A 5g08A-4y23A:
undetectable		 5g08A-4y23A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 HIS A 401
THR A 403
GLN A 552
GLY A 478
SER A 283
 None
 1.33A 5hfjB-4y23A:
undetectable		 5hfjB-4y23A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 7 ILE A 396
GLY A 397
PHE A  92
ASP A 441
 None
None
None
NA  A 601 (-3.3A)
 1.04A 5hieA-4y23A:
undetectable		 5hieA-4y23A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.09A 5lf7V-4y23A:
2.8
5lf7b-4y23A:
undetectable		 5lf7V-4y23A:
18.24
5lf7b-4y23A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.09A 5lf7H-4y23A:
2.8
5lf7N-4y23A:
undetectable		 5lf7H-4y23A:
18.24
5lf7N-4y23A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 9 ILE A 245
VAL A 141
ASP A 251
ILE A 426
 None
 1.05A 5lg3I-4y23A:
undetectable		 5lg3I-4y23A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 9 TYR A  75
LEU A 433
LEU A 261
TYR A 431
THR A 224
 None
 1.32A 5mxbA-4y23A:
undetectable		 5mxbA-4y23A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 6 ARG A 136
GLY A 425
THR A 197
SER A 195
 None
 0.70A 5ny7A-4y23A:
undetectable		 5ny7A-4y23A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 LEU A 427
GLN A 218
VAL A 217
PHE A 434
LEU A 204
 None
 1.34A 5uc3B-4y23A:
undetectable		 5uc3B-4y23A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		3 / 3 GLY A 242
THR A 416
PRO A 144
 None
 0.62A 5v5zA-4y23A:
undetectable		 5v5zA-4y23A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 LEU A 433
ILE A 241
ALA A 235
ILE A  71
GLY A 149
 None
 0.95A 5veuB-4y23A:
undetectable		 5veuB-4y23A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		6 / 10 VAL A  39
GLY A  40
GLY A  43
LEU A 503
ILE A 556
THR A 562
 None
 1.39A 5vm8B-4y23A:
undetectable		 5vm8B-4y23A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 TYR A 328
MET A 324
THR A 323
LEU A 320
 None
 1.16A 5w97J-4y23A:
undetectable		 5w97J-4y23A:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 ALA A 282
THR A 463
GLY A 291
THR A 103
PHE A 468
 None
 1.06A 5ybbA-4y23A:
undetectable		 5ybbA-4y23A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 8 LEU A 421
GLU A  81
LEU A 183
LEU A 194
 None
 0.82A 6cbzA-4y23A:
undetectable		 6cbzA-4y23A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 LEU A 261
TYR A 237
ILE A 170
GLY A 145
 None
 0.99A 6hd6A-4y23A:
undetectable		 6hd6A-4y23A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 SER A 460
THR A 417
THR A 416
THR A 415
ALA A 399
 NA  A 601 ( 4.4A)
NA  A 601 ( 4.7A)
None
None
None
 0.83A 6hwdV-4y23A:
undetectable
6hwdb-4y23A:
undetectable		 6hwdV-4y23A:
10.02
6hwdb-4y23A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.14A 6hwdV-4y23A:
undetectable
6hwdb-4y23A:
undetectable		 6hwdV-4y23A:
10.02
6hwdb-4y23A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 SER A 460
THR A 417
THR A 416
THR A 415
ALA A 399
 NA  A 601 ( 4.4A)
NA  A 601 ( 4.7A)
None
None
None
 0.84A 6hwdH-4y23A:
undetectable
6hwdN-4y23A:
undetectable		 6hwdH-4y23A:
10.02
6hwdN-4y23A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		5 / 12 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.14A 6hwdH-4y23A:
undetectable
6hwdN-4y23A:
undetectable		 6hwdH-4y23A:
10.02
6hwdN-4y23A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 TYR A 328
MET A 324
THR A 323
LEU A 320
 None
 1.14A 6nknJ-4y23A:
undetectable		 6nknJ-4y23A:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE
(Bacillus
licheniformis) 		4 / 5 TYR A 328
MET A 324
THR A 323
LEU A 320
 None
 1.17A 6nknW-4y23A:
undetectable		 6nknW-4y23A:
6.96