SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 517
ASN A 516
ARG A 806
 None
 0.90A 2qhfA-4y25A:
undetectable		 2qhfA-4y25A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		5 / 9 LEU A 591
LEU A 610
ILE A 545
GLU A 594
GLU A 627
 None
 1.16A 3tmzA-4y25A:
undetectable		 3tmzA-4y25A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		4 / 7 THR A 719
ASN A 715
TYR A 714
TYR A 702
 None
 1.24A 4a3uA-4y25A:
undetectable		 4a3uA-4y25A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		4 / 8 SER A 586
ASN A 588
ILE A 589
ASN A 554
 None
 0.98A 4d33A-4y25A:
undetectable		 4d33A-4y25A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		4 / 7 SER A 586
ASN A 588
ILE A 589
ASN A 554
 None
 0.97A 4d33B-4y25A:
undetectable		 4d33B-4y25A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		4 / 7 SER A 586
ASN A 588
ILE A 589
ASN A 554
 None
 1.03A 4d39B-4y25A:
undetectable		 4d39B-4y25A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		5 / 12 ARG A 609
GLU A 592
GLU A 583
GLY A 612
TYR A 547
 None
 1.34A 4ffwB-4y25A:
undetectable		 4ffwB-4y25A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 725
PRO A 724
GLY A 747
GLY A 749
GLU A 800
 None
 0.98A 5c0oG-4y25A:
undetectable		 5c0oG-4y25A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		4 / 5 GLU A 678
THR A 668
GLU A 627
LEU A 635
 None
 1.14A 5hm8G-4y25A:
undetectable		 5hm8G-4y25A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN
(Escherichia
coli) 		4 / 8 GLY A 747
GLN A 763
THR A 762
PHE A 744
 None
 0.99A 6eqpA-4y25A:
undetectable		 6eqpA-4y25A:
13.83