SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q2H_B_ACTB501_0 (SECRETION CHAPERONE, PHAGE-DISPLAY DERIVED PEPTIDE)	4y2e	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7 (Homo sapiens)	3 / 3	ARG A 222 SER A 223 TYR A 246	None	0.92A	2q2hA-4y2eA: undetectable 2q2hB-4y2eA: undetectable	2q2hA-4y2eA: 22.84 2q2hB-4y2eA: 22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y01_B_Y00B601_1 (BETA-1 ADRENERGIC RECEPTOR)	4y2e	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7 (Homo sapiens)	5 / 12	LEU A 229 VAL A 228 THR A 162 ASN A 181 TYR A 194	None	1.28A	2y01B-4y2eA: undetectable	2y01B-4y2eA: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ARU_A_PNXA608_1 (CHITINASE A)	4y2e	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7 (Homo sapiens)	4 / 6	ASN A 274 SER A 204 HIS A 202 ASP A 201	None None None PO4 A 301 (-3.2A)	1.38A	3aruA-4y2eA: undetectable	3aruA-4y2eA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VW3_A_ACTA404_0 (FERREDOXIN--NADP REDUCTASE)	4y2e	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7 (Homo sapiens)	4 / 4	GLN A 209 LEU A 207 ASN A 206 GLN A 278	None	1.31A	5vw3A-4y2eA: 0.0	5vw3A-4y2eA: 21.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2Q2H_B_ACTB501_0","SECRETION CHAPERONE, PHAGE-DISPLAY DERIVED PEPTIDE","4y2e","DUAL SPECIFICITY PROTEIN PHOSPHATASE 7","Homo sapiens",3,"ARG A 222;SER A 223;TYR A 246","None","0.92A","2q2hA-4y2eA:undetectable;2q2hB-4y2eA:undetectable","2q2hA-4y2eA:22.84;2q2hB-4y2eA:22.84"],["2Y01_B_Y00B601_1","BETA-1 ADRENERGIC RECEPTOR","4y2e","DUAL SPECIFICITY PROTEIN PHOSPHATASE 7","Homo sapiens",5,"LEU A 229;VAL A 228;THR A 162;ASN A 181;TYR A 194","None","1.28A","2y01B-4y2eA:undetectable","2y01B-4y2eA:20.45"],["3ARU_A_PNXA608_1","CHITINASE A","4y2e","DUAL SPECIFICITY PROTEIN PHOSPHATASE 7","Homo sapiens",4,"ASN A 274;SER A 204;HIS A 202;ASP A 201","None;None;None;PO4 A 301 (-3.2A)","1.38A","3aruA-4y2eA:undetectable","3aruA-4y2eA:14.60"],["5VW3_A_ACTA404_0","FERREDOXIN--NADP REDUCTASE","4y2e","DUAL SPECIFICITY PROTEIN PHOSPHATASE 7","Homo sapiens",4,"GLN A 209;LEU A 207;ASN A 206;GLN A 278","None","1.31A","5vw3A-4y2eA:0.0","5vw3A-4y2eA:21.18"]]