SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4y2l CFA/I FIMBRIAL
SUBUNIT B
(Escherichia
coli) 		5 / 12 ALA A  63
LEU A 141
ILE A 119
LEU A 117
LEU A  89
 None
 0.99A 3k2hA-4y2lA:
undetectable		 3k2hA-4y2lA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4y2l CFA/I FIMBRIAL
SUBUNIT B
(Escherichia
coli) 		5 / 12 LEU A  17
VAL A  60
VAL A  58
LEU A 101
PHE A  96
 None
 0.85A 4y0pA-4y2lA:
undetectable		 4y0pA-4y2lA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4y2l CFA/I FIMBRIAL
SUBUNIT B
(Escherichia
coli) 		5 / 9 LEU A  31
SER A  42
ILE A  80
VAL A 139
ILE A 119
 None
 1.28A 6ef6A-4y2lA:
undetectable		 6ef6A-4y2lA:
19.33