SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4y2o CFA/I FIMBRIAL
SUBUNIT A
(COLONIZATION FACTOR
ANTIGEN SUBUNIT A
PUTATIVE CHAPERONE)
CFA/I FIMBRIAL
SUBUNIT B
(Escherichia
coli) 		3 / 3 GLU A 205
HIS B  -3
HIS B  -4
 None
NI  B 201 (-4.0A)
None
 0.81A 3co4A-4y2oA:
undetectable		 3co4A-4y2oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 4y2o CFA/I FIMBRIAL
SUBUNIT A
(COLONIZATION FACTOR
ANTIGEN SUBUNIT A
PUTATIVE CHAPERONE)
CFA/I FIMBRIAL
SUBUNIT B
(Escherichia
coli) 		4 / 4 PHE A  93
TYR A  22
VAL A 116
LEU B 128
 None
 1.47A 3keeD-4y2oA:
undetectable		 3keeD-4y2oA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4y2o CFA/I FIMBRIAL
SUBUNIT A
(COLONIZATION FACTOR
ANTIGEN SUBUNIT A
PUTATIVE CHAPERONE)
(Escherichia
coli) 		5 / 10 PHE A 187
ILE A 181
THR A 189
ILE A 160
VAL A 157
 None
 1.04A 3me6A-4y2oA:
undetectable		 3me6A-4y2oA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4y2o CFA/I FIMBRIAL
SUBUNIT A
(COLONIZATION FACTOR
ANTIGEN SUBUNIT A
PUTATIVE CHAPERONE)
(Escherichia
coli) 		4 / 5 ILE A  51
ILE A  39
TYR A  89
GLU A  87
 None
 1.20A 4zzcE-4y2oA:
undetectable		 4zzcE-4y2oA:
21.52