SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		5 / 9 ILE A 130
LEU A 162
GLU A 116
ALA A 112
VAL A 106
 None
 0.94A 1ctrA-4y2wA:
undetectable		 1ctrA-4y2wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		5 / 11 VAL A  11
ILE A 338
ILE A 337
VAL A 362
PHE A 363
 None
 1.11A 1gx9A-4y2wA:
undetectable		 1gx9A-4y2wA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 8 PHE A 363
ILE A 338
ASP A 289
GLY A 290
 None
 0.82A 1rtsA-4y2wA:
undetectable		 1rtsA-4y2wA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		3 / 3 ARG A 369
ARG A   7
ILE A 366
 None
 0.80A 1uobA-4y2wA:
undetectable		 1uobA-4y2wA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		3 / 3 LYS A 241
ASP A 175
ASP A 178
 None
 1.11A 2br4A-4y2wA:
undetectable		 2br4A-4y2wA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A 170
ILE A 206
SER A 167
ALA A 211
ASP A 176
 None
 1.17A 2ejtA-4y2wA:
undetectable		 2ejtA-4y2wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 7 LEU A  74
ILE A  39
ALA A 207
ILE A 212
 None
 0.75A 2xkwA-4y2wA:
undetectable		 2xkwA-4y2wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A 211
ALA A 209
VAL A  38
VAL A 223
ARG A 224
 None
PO4  A 401 (-3.1A)
None
None
None
 1.11A 3cwkA-4y2wA:
undetectable		 3cwkA-4y2wA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		5 / 9 VAL A  51
ILE A  39
GLY A 226
ILE A 228
ILE A  18
 None
None
PO4  A 401 (-3.7A)
None
None
 1.13A 3ekqB-4y2wA:
undetectable		 3ekqB-4y2wA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		5 / 9 ARG A  23
ALA A  37
VAL A  51
ILE A 228
THR A  19
 None
 1.29A 3spkA-4y2wA:
undetectable		 3spkA-4y2wA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A 147
GLY A 140
LYS A 113
LEU A 115
GLU A 116
 None
 0.94A 5c0oH-4y2wA:
2.0		 5c0oH-4y2wA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 5 VAL A 370
VAL A 285
GLY A 286
PHE A 250
 None
 0.90A 5d4nA-4y2wA:
undetectable
5d4nC-4y2wA:
undetectable		 5d4nA-4y2wA:
16.94
5d4nC-4y2wA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 5 GLN A 104
HIS A 129
ILE A 130
TYR A 111
 None
 1.23A 5dnuA-4y2wA:
undetectable		 5dnuA-4y2wA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 7 PHE A 363
ILE A 338
ASP A 289
GLY A 290
 None
 0.80A 5h3aA-4y2wA:
undetectable		 5h3aA-4y2wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 7 PHE A 363
ILE A 338
ASP A 289
GLY A 290
 None
 0.78A 5h3aB-4y2wA:
undetectable		 5h3aB-4y2wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		5 / 12 ASP A 353
ALA A 352
GLY A 339
THR A 251
SER A 350
 None
 1.26A 5hfjH-4y2wA:
undetectable		 5hfjH-4y2wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 8 ILE A 227
GLU A 361
ALA A 352
THR A 357
 PO4  A 401 (-4.4A)
None
None
None
 0.78A 5og9A-4y2wA:
undetectable		 5og9A-4y2wA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 7 PHE A 363
ILE A 338
ASP A 289
GLY A 290
 None
 0.84A 5x5qC-4y2wA:
undetectable		 5x5qC-4y2wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 8 PHE A 363
ILE A 338
ASP A 289
GLY A 290
 None
 0.83A 5x5qD-4y2wA:
undetectable		 5x5qD-4y2wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4y2w ALANINE RACEMASE 1
(Caldanaerobacter
subterraneus) 		4 / 8 PHE A 363
ILE A 338
ASP A 289
GLY A 290
 None
 0.84A 5x5qF-4y2wA:
undetectable		 5x5qF-4y2wA:
21.75