SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 134
LEU A  65
GLY A  43
LEU A  49
 None
None
48F  A 301 (-3.4A)
None
 0.82A 1gtiA-4y4mA:
undetectable		 1gtiA-4y4mA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 134
LEU A  65
GLY A  43
LEU A  49
 None
None
48F  A 301 (-3.4A)
None
 0.85A 1gtiB-4y4mA:
undetectable		 1gtiB-4y4mA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 134
LEU A  65
GLY A  43
LEU A  49
 None
None
48F  A 301 (-3.4A)
None
 0.79A 1gtiE-4y4mA:
undetectable		 1gtiE-4y4mA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 141
LEU A 225
VAL A  42
ALA A 183
ALA A 231
 None
 1.14A 1n5xA-4y4mA:
undetectable		 1n5xA-4y4mA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 141
LEU A 225
VAL A  42
ALA A 183
ALA A 231
 None
 1.14A 1n5xB-4y4mA:
undetectable		 1n5xB-4y4mA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 180
ALA A 231
ALA A 232
LEU A 214
VAL A 176
 48F  A 301 (-3.3A)
None
None
None
None
 1.13A 1ukbA-4y4mA:
undetectable		 1ukbA-4y4mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 185
LEU A 225
ASN A 224
ASN A 193
VAL A  40
 None
 1.17A 2nnhB-4y4mA:
undetectable		 2nnhB-4y4mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 102
GLU A  93
ILE A 100
GLY A  99
LEU A  94
 None
 1.16A 2qmmA-4y4mA:
undetectable		 2qmmA-4y4mA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 132
ALA A 125
ALA A 130
LEU A  49
ILE A 136
 None
 1.03A 3falC-4y4mA:
undetectable		 3falC-4y4mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 132
ALA A 125
ALA A 130
LEU A  49
ILE A 136
 None
 0.99A 3fc6A-4y4mA:
undetectable		 3fc6A-4y4mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  72
GLY A  73
GLY A  74
SER A 114
ALA A 122
 None
48F  A 301 (-3.1A)
48F  A 301 (-3.9A)
None
None
 0.92A 4htfA-4y4mA:
undetectable		 4htfA-4y4mA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  72
GLY A  73
GLY A  74
SER A 114
ALA A 122
 None
48F  A 301 (-3.1A)
48F  A 301 (-3.9A)
None
None
 0.95A 4htfB-4y4mA:
undetectable		 4htfB-4y4mA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ASP A 177
ALA A 231
GLY A 201
VAL A 221
VAL A 227
 None
None
None
NHE  A 302 (-4.0A)
None
 0.98A 4j5jB-4y4mA:
undetectable		 4j5jB-4y4mA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 130
ALA A 124
ALA A 128
VAL A  62
GLY A  48
 None
 1.00A 4qvyK-4y4mA:
undetectable
4qvyL-4y4mA:
undetectable		 4qvyK-4y4mA:
25.77
4qvyL-4y4mA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 130
ALA A 124
ALA A 128
VAL A  62
GLY A  48
 None
 1.00A 4qvyY-4y4mA:
undetectable
4qvyZ-4y4mA:
undetectable		 4qvyY-4y4mA:
25.77
4qvyZ-4y4mA:
21.28