SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 7 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.74A 1gtiA-4y4nA:
undetectable		 1gtiA-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 7 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.84A 1gtiB-4y4nA:
undetectable		 1gtiB-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 7 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.98A 1gtiD-4y4nA:
undetectable		 1gtiD-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 7 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.73A 1gtiE-4y4nA:
undetectable		 1gtiE-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 4 ALA A 178
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.16A 1q23A-4y4nA:
undetectable		 1q23A-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 4 ALA A 227
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.15A 1q23A-4y4nA:
undetectable		 1q23A-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 4 ALA A 178
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.16A 1q23F-4y4nA:
undetectable		 1q23F-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 4 ALA A 227
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.23A 1q23F-4y4nA:
undetectable		 1q23F-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 4 ALA A 178
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.22A 1q23K-4y4nA:
undetectable		 1q23K-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 4 ALA A 227
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.17A 1q23K-4y4nA:
undetectable		 1q23K-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 ILE A 148
VAL A 146
VAL A  30
ILE A  27
ILE A 131
 None
 1.30A 1r5lA-4y4nA:
undetectable		 1r5lA-4y4nA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 5 PRO A  39
ILE A 240
GLY A 242
TYR A 245
 48H  A 302 (-3.4A)
None
None
None
 1.12A 2jkjD-4y4nA:
undetectable		 2jkjD-4y4nA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 5 PRO A  39
ILE A 240
GLY A 242
TYR A 245
 48H  A 302 (-3.4A)
None
None
None
 1.12A 2jkjF-4y4nA:
undetectable		 2jkjF-4y4nA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 8 TYR A 169
GLY A 220
PRO A 219
GLU A 216
 None
 1.02A 2ys6A-4y4nA:
3.5		 2ys6A-4y4nA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 10 ALA A  44
ALA A  45
ALA A 252
VAL A 146
ILE A 165
 None
 1.10A 3falA-4y4nA:
undetectable		 3falA-4y4nA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 VAL A  35
ALA A  44
ALA A  45
ALA A 252
VAL A 146
 48H  A 302 (-4.9A)
None
None
None
None
 0.86A 3fc6C-4y4nA:
undetectable		 3fc6C-4y4nA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 VAL A 195
TYR A 232
GLY A 192
SER A 185
LEU A 184
 None
 1.01A 3hs6A-4y4nA:
undetectable		 3hs6A-4y4nA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 LEU A  95
VAL A  80
THR A  68
HIS A 176
LEU A 116
 None
None
None
FE2  A 301 ( 3.4A)
None
 1.25A 3sp9B-4y4nA:
undetectable		 3sp9B-4y4nA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 THR A 214
GLY A 225
GLY A 243
ASP A 172
GLU A 216
 None
48H  A 302 (-3.5A)
None
None
None
 1.38A 3tkaA-4y4nA:
2.5		 3tkaA-4y4nA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 ILE A  27
GLY A  36
VAL A 146
ILE A 148
VAL A 133
 None
48H  A 302 (-3.2A)
None
None
48H  A 302 (-4.2A)
 1.02A 4c9lA-4y4nA:
undetectable		 4c9lA-4y4nA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 ILE A  27
GLY A  36
VAL A 146
ILE A 148
VAL A 133
 None
48H  A 302 (-3.2A)
None
None
48H  A 302 (-4.2A)
 1.05A 4c9lB-4y4nA:
undetectable		 4c9lB-4y4nA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 ILE A  27
GLY A  36
VAL A 146
ILE A 148
VAL A 133
 None
48H  A 302 (-3.2A)
None
None
48H  A 302 (-4.2A)
 1.00A 4c9oA-4y4nA:
undetectable		 4c9oA-4y4nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 ILE A  27
GLY A  36
VAL A 146
ILE A 148
VAL A 133
 None
48H  A 302 (-3.2A)
None
None
48H  A 302 (-4.2A)
 1.00A 4c9oB-4y4nA:
undetectable		 4c9oB-4y4nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 GLY A  65
GLY A  66
GLY A  67
SER A 109
ALA A 117
 None
48H  A 302 (-2.8A)
48H  A 302 (-3.8A)
None
None
 0.97A 4htfA-4y4nA:
2.7		 4htfA-4y4nA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 10 ASP A 172
ALA A 227
GLY A 197
VAL A 217
VAL A 223
 None
 0.95A 4j5jB-4y4nA:
undetectable		 4j5jB-4y4nA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JI8_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		3 / 3 LYS A 205
LYS A 199
TRP A 202
 None
 1.31A 4ji8L-4y4nA:
undetectable		 4ji8L-4y4nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 GLY A 119
TYR A  47
ALA A  45
ASP A 122
ALA A 123
 None
 1.37A 4ymgB-4y4nA:
2.7		 4ymgB-4y4nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 GLU A  81
GLY A 242
GLY A 243
ASN A 229
GLY A 225
 None
None
None
None
48H  A 302 (-3.5A)
 1.16A 6gneB-4y4nA:
3.7		 6gneB-4y4nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 9 ILE A 165
ILE A  28
GLU A  59
VAL A  56
ILE A  27
 None
None
48H  A 302 (-2.7A)
None
None
 1.34A 6hloA-4y4nA:
3.2		 6hloA-4y4nA:
20.57