SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.21A 3dqrA-4y4qA:
undetectable
3dqrB-4y4qA:
undetectable		 3dqrA-4y4qA:
21.03
3dqrB-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.20A 3jx2A-4y4qA:
undetectable
3jx2B-4y4qA:
undetectable		 3jx2A-4y4qA:
21.03
3jx2B-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.20A 3jx3A-4y4qA:
undetectable
3jx3B-4y4qA:
undetectable		 3jx3A-4y4qA:
21.03
3jx3B-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.15A 3jx5A-4y4qA:
undetectable
3jx5B-4y4qA:
undetectable		 3jx5A-4y4qA:
21.03
3jx5B-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 VAL A  94
ARG A 225
VAL A 252
PHE A 167
 None
 1.15A 3jx6A-4y4qA:
undetectable
3jx6B-4y4qA:
undetectable		 3jx6A-4y4qA:
21.03
3jx6B-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.15A 3jx6A-4y4qA:
undetectable
3jx6B-4y4qA:
undetectable		 3jx6A-4y4qA:
21.03
3jx6B-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.15A 3nljA-4y4qA:
undetectable
3nljB-4y4qA:
undetectable		 3nljA-4y4qA:
21.03
3nljB-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.19A 3nlpA-4y4qA:
undetectable
3nlpB-4y4qA:
undetectable		 3nlpA-4y4qA:
21.03
3nlpB-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		3 / 3 ASN A 247
ALA A 194
ARG A 249
 None
 0.80A 3tj7C-4y4qA:
undetectable
3tj7D-4y4qA:
undetectable		 3tj7C-4y4qA:
21.48
3tj7D-4y4qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 VAL A  94
ARG A 225
VAL A 252
PHE A 167
 None
 1.23A 4cx3A-4y4qA:
undetectable
4cx3B-4y4qA:
undetectable		 4cx3A-4y4qA:
21.03
4cx3B-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.21A 4cx4A-4y4qA:
undetectable
4cx4B-4y4qA:
undetectable		 4cx4A-4y4qA:
21.03
4cx4B-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.20A 5addA-4y4qA:
undetectable
5addB-4y4qA:
undetectable		 5addA-4y4qA:
21.03
5addB-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 167
VAL A  94
ARG A 225
VAL A 252
 None
 1.12A 5adeA-4y4qA:
undetectable
5adeB-4y4qA:
undetectable		 5adeA-4y4qA:
21.03
5adeB-4y4qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		5 / 12 ILE A  99
TYR A 101
PHE A 161
LEU A 184
GLY A 156
 None
 1.11A 5i71A-4y4qA:
undetectable		 5i71A-4y4qA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		5 / 12 ILE A  99
TYR A 101
PHE A 161
LEU A 184
GLY A 156
 None
 1.15A 5i75A-4y4qA:
undetectable		 5i75A-4y4qA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4y4q SORTASE, SRTB FAMILY
(Streptococcus
pneumoniae) 		4 / 5 LEU A 237
VAL A 253
GLU A 188
LEU A 217
 None
 1.09A 5xooB-4y4qA:
undetectable		 5xooB-4y4qA:
15.88