SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		3 / 3 PHE A 319
TRP A 223
GLU A 224
 None
 0.97A 1mogA-4y4rA:
undetectable		 1mogA-4y4rA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 8 MET A 538
LEU A 587
SER A 198
VAL A 559
 None
 0.82A 2qd2A-4y4rA:
undetectable		 2qd2A-4y4rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 8 MET A 538
LEU A 587
SER A 198
VAL A 559
 None
 0.86A 2qd5A-4y4rA:
undetectable		 2qd5A-4y4rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 8 MET A 538
LEU A 587
SER A 198
VAL A 559
 None
 0.84A 2qd5B-4y4rA:
undetectable		 2qd5B-4y4rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		5 / 9 GLY A 320
SER A 421
LEU A 420
SER A 325
LEU A 312
 None
 0.95A 3ai9X-4y4rA:
undetectable		 3ai9X-4y4rA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		3 / 3 GLU A 352
HIS A 414
THR A 244
 None
 0.65A 3hkuA-4y4rA:
undetectable		 3hkuA-4y4rA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 4 LEU A 299
ILE A 344
TYR A 565
TYR A 328
 None
None
None
ACT  A 702 (-3.4A)
 1.46A 3vt7A-4y4rA:
undetectable		 3vt7A-4y4rA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 4 VAL A 559
GLU A 560
GLY A 618
LEU A 619
 None
 0.72A 5g5gC-4y4rA:
undetectable		 5g5gC-4y4rA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 5 GLU A 592
GLU A 535
THR A 534
LEU A 620
 None
 1.25A 5hm8A-4y4rA:
undetectable		 5hm8A-4y4rA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 5 GLU A 592
GLU A 535
THR A 534
LEU A 620
 None
 1.25A 5hm8B-4y4rA:
undetectable		 5hm8B-4y4rA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 5 GLU A 592
GLU A 535
THR A 534
LEU A 620
 None
 1.24A 5hm8C-4y4rA:
undetectable		 5hm8C-4y4rA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 5 GLU A 592
GLU A 535
THR A 534
LEU A 620
 None
 1.24A 5hm8D-4y4rA:
undetectable		 5hm8D-4y4rA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 5 GLU A 592
GLU A 535
THR A 534
LEU A 620
 None
 1.24A 5hm8E-4y4rA:
undetectable		 5hm8E-4y4rA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 5 GLU A 592
GLU A 535
THR A 534
LEU A 620
 None
 1.24A 5hm8F-4y4rA:
undetectable		 5hm8F-4y4rA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 5 GLU A 592
GLU A 535
THR A 534
LEU A 620
 None
 1.25A 5hm8H-4y4rA:
undetectable		 5hm8H-4y4rA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		3 / 3 THR A 422
SER A 321
ASP A 430
 None
 0.87A 5kvaB-4y4rA:
undetectable		 5kvaB-4y4rA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		5 / 12 GLN A 540
LEU A 315
GLN A 316
GLU A 317
SER A 509
 None
 1.42A 5l8oB-4y4rA:
1.0		 5l8oB-4y4rA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		5 / 12 GLY A 320
SER A 421
LEU A 420
SER A 325
LEU A 312
 None
 0.74A 5twjA-4y4rA:
undetectable		 5twjA-4y4rA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		5 / 12 GLY A 320
SER A 421
LEU A 420
SER A 325
LEU A 312
 None
 0.74A 5twjC-4y4rA:
undetectable		 5twjC-4y4rA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 7 ALA A 611
THR A 612
TYR A 615
VAL A 596
 None
 0.94A 6cduA-4y4rA:
undetectable
6cduE-4y4rA:
undetectable		 6cduA-4y4rA:
21.37
6cduE-4y4rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 7 VAL A 596
ALA A 611
THR A 612
TYR A 615
 None
 0.94A 6cduH-4y4rA:
undetectable
6cduI-4y4rA:
undetectable		 6cduH-4y4rA:
21.37
6cduI-4y4rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 6 TYR A 615
VAL A 596
VAL A 536
THR A 622
 None
 1.41A 6f32B-4y4rA:
undetectable		 6f32B-4y4rA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 4 GLN A 540
THR A 515
THR A 307
LEU A 205
 None
 1.49A 6f3mB-4y4rA:
undetectable		 6f3mB-4y4rA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		4 / 6 MET A 538
ALA A 582
LEU A 610
ALA A 611
 None
 1.12A 6fosB-4y4rA:
undetectable		 6fosB-4y4rA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens) 		5 / 12 LEU A 539
GLY A 618
ASP A 598
SER A 522
VAL A 523
 None
 1.06A 6mhtA-4y4rA:
undetectable		 6mhtA-4y4rA:
21.32