SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_A_SAMA1500_0 (ASPARTOKINASE)	4y4s	EXTRACELLULAR HEME ACQUISITION HEMOPHORE HASA (Yersinia pseudotuberculos is)	4 / 8	ILE A 87 SER A 122 ASP A 120 GLU A 70	None	0.84A	2cdqA-4y4sA: undetectable	2cdqA-4y4sA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RUN_A_CCSA165_0 (LYSOZYME)	4y4s	EXTRACELLULAR HEME ACQUISITION HEMOPHORE HASA (Yersinia pseudotuberculos is)	3 / 3	ASN A 99 ALA A 105 LYS A 107	None	1.01A	3runA-4y4sA: undetectable	3runA-4y4sA: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IM2_A_BEZA401_0 (TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL)	4y4s	EXTRACELLULAR HEME ACQUISITION HEMOPHORE HASA (Yersinia pseudotuberculos is)	5 / 12	PHE A 125 MET A 139 VAL A 143 LEU A 121 LEU A 119	None	1.17A	5im2A-4y4sA: undetectable	5im2A-4y4sA: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_D_SAMD501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	4y4s	EXTRACELLULAR HEME ACQUISITION HEMOPHORE HASA (Yersinia pseudotuberculos is)	5 / 10	HIS A 84 ILE A 87 GLY A 71 GLY A 52 ALA A 69	HEM A 301 (-3.3A) None None None None	1.02A	5o96C-4y4sA: undetectable 5o96D-4y4sA: undetectable	5o96C-4y4sA: 22.31 5o96D-4y4sA: 22.31

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2CDQ_A_SAMA1500_0","ASPARTOKINASE","4y4s","EXTRACELLULAR HEME ACQUISITION HEMOPHORE HASA","Yersinia pseudotuberculosis",4,"ILE A  87;SER A 122;ASP A 120;GLU A  70","None","0.84A","2cdqA-4y4sA:undetectable","2cdqA-4y4sA:17.65"],["3RUN_A_CCSA165_0","LYSOZYME","4y4s","EXTRACELLULAR HEME ACQUISITION HEMOPHORE HASA","Yersinia pseudotuberculosis",3,"ASN A  99;ALA A 105;LYS A 107","None","1.01A","3runA-4y4sA:undetectable","3runA-4y4sA:20.81"],["5IM2_A_BEZA401_0","TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL","4y4s","EXTRACELLULAR HEME ACQUISITION HEMOPHORE HASA","Yersinia pseudotuberculosis",5,"PHE A 125;MET A 139;VAL A 143;LEU A 121;LEU A 119","None","1.17A","5im2A-4y4sA:undetectable","5im2A-4y4sA:20.97"],["5O96_D_SAMD501_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E","4y4s","EXTRACELLULAR HEME ACQUISITION HEMOPHORE HASA","Yersinia pseudotuberculosis",5,"HIS A  84;ILE A  87;GLY A  71;GLY A  52;ALA A  69","HEM A 301 (-3.3A);None;None;None;None","1.02A","5o96C-4y4sA:undetectable;5o96D-4y4sA:undetectable","5o96C-4y4sA:22.31;5o96D-4y4sA:22.31"]]