SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 6 LEU A 184
ASP A 188
LEU A 191
GLY A 193
 None
 0.49A 1mt1G-4y4vA:
undetectable
1mt1J-4y4vA:
undetectable		 1mt1G-4y4vA:
9.14
1mt1J-4y4vA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 7 LEU A 184
ASP A 188
LEU A 191
GLY A 193
 None
 0.51A 1mt1H-4y4vA:
undetectable
1mt1K-4y4vA:
undetectable		 1mt1H-4y4vA:
14.41
1mt1K-4y4vA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 6 LEU A 184
ASP A 188
LEU A 191
GLY A 193
 None
 0.49A 1n13H-4y4vA:
undetectable
1n13K-4y4vA:
undetectable		 1n13H-4y4vA:
14.41
1n13K-4y4vA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 7 LEU A 184
ASP A 188
LEU A 191
GLY A 193
 None
 0.50A 1n13G-4y4vA:
undetectable
1n13J-4y4vA:
undetectable		 1n13G-4y4vA:
9.14
1n13J-4y4vA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 7 SER A 274
ASP A 294
SER A 273
ASN A  66
 None
 0.96A 2cmlA-4y4vA:
undetectable		 2cmlA-4y4vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 SER A 274
ASP A 294
SER A 273
ASN A  66
 None
 1.02A 2cmlB-4y4vA:
undetectable		 2cmlB-4y4vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 SER A 274
ASP A 294
SER A 273
ASN A  66
 None
 0.96A 2cmlC-4y4vA:
undetectable		 2cmlC-4y4vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 SER A 274
ASP A 294
SER A 273
ASN A  66
 None
 1.09A 2cmlD-4y4vA:
undetectable		 2cmlD-4y4vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 TYR A 146
ASP A 147
TYR A 316
TYR A 120
 None
 1.24A 2ha2A-4y4vA:
undetectable		 2ha2A-4y4vA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 TYR A 146
ASP A 147
TYR A 316
TYR A 120
 None
 1.25A 2ha2B-4y4vA:
undetectable		 2ha2B-4y4vA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 7 LYS A  92
SER A  79
VAL A  72
SER A  95
 GOL  A 403 ( 4.6A)
None
None
None
 1.29A 2j9cA-4y4vA:
undetectable
2j9cB-4y4vA:
undetectable
2j9cC-4y4vA:
undetectable		 2j9cA-4y4vA:
16.72
2j9cB-4y4vA:
16.72
2j9cC-4y4vA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 7 LEU A 184
ASP A 188
LEU A 191
GLY A 193
 None
 0.55A 2qqcD-4y4vA:
undetectable
2qqcE-4y4vA:
undetectable		 2qqcD-4y4vA:
15.91
2qqcE-4y4vA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 LEU A 184
ASP A 188
LEU A 191
GLY A 193
 None
 0.48A 2qqdB-4y4vA:
undetectable
2qqdC-4y4vA:
undetectable		 2qqdB-4y4vA:
15.91
2qqdC-4y4vA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 THR A 173
VAL A 100
ILE A 177
GLU A 180
PRO A  78
 CSO  A 176 ( 2.7A)
CSO  A 176 ( 4.3A)
CSO  A 176 ( 4.1A)
None
None
 1.19A 2yzqA-4y4vA:
undetectable		 2yzqA-4y4vA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 11 LEU A 315
VAL A 324
TYR A 239
TRP A 223
LEU A 220
 None
 1.21A 3m8pA-4y4vA:
undetectable
3m8pB-4y4vA:
undetectable		 3m8pA-4y4vA:
22.05
3m8pB-4y4vA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 315
VAL A 324
TYR A 239
TRP A 223
LEU A 220
 None
 1.27A 3mecA-4y4vA:
2.0		 3mecA-4y4vA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 315
VAL A 324
TYR A 239
TRP A 223
LEU A 220
 None
 1.20A 3medA-4y4vA:
undetectable
3medB-4y4vA:
undetectable		 3medA-4y4vA:
22.22
3medB-4y4vA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 10 ASP A 106
ASN A 282
TYR A 120
ILE A 117
GLY A 118
 None
 1.41A 3myuB-4y4vA:
undetectable		 3myuB-4y4vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 TYR A  64
ASN A  88
ILE A 199
LEU A 213
 None
 0.98A 3rqwI-4y4vA:
undetectable
3rqwJ-4y4vA:
undetectable		 3rqwI-4y4vA:
21.63
3rqwJ-4y4vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 TYR A 280
SER A 283
ASP A 147
ILE A 157
 None
None
None
CSO  A 176 ( 4.7A)
 1.38A 3uj7B-4y4vA:
undetectable		 3uj7B-4y4vA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 4 LEU A  80
ILE A 278
TYR A 120
TYR A  83
 None
 1.43A 3vt7A-4y4vA:
undetectable		 3vt7A-4y4vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 VAL A 119
GLY A 118
TYR A 146
ASP A 147
 None
 1.36A 3w9tA-4y4vA:
undetectable		 3w9tA-4y4vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 VAL A 119
GLY A 118
TYR A 146
ASP A 147
 None
 1.35A 3w9tB-4y4vA:
undetectable		 3w9tB-4y4vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 VAL A 119
GLY A 118
TYR A 146
ASP A 147
 None
 1.36A 3w9tC-4y4vA:
undetectable		 3w9tC-4y4vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 VAL A 119
GLY A 118
TYR A 146
ASP A 147
 None
 1.35A 3w9tD-4y4vA:
undetectable		 3w9tD-4y4vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 VAL A 119
GLY A 118
TYR A 146
ASP A 147
 None
 1.36A 3w9tE-4y4vA:
undetectable		 3w9tE-4y4vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 VAL A 119
GLY A 118
TYR A 146
ASP A 147
 None
 1.36A 3w9tF-4y4vA:
undetectable		 3w9tF-4y4vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 VAL A 119
GLY A 118
TYR A 146
ASP A 147
 None
 1.36A 3w9tG-4y4vA:
undetectable		 3w9tG-4y4vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 6 TYR A 146
ASP A 147
TYR A 316
TYR A 120
 None
 1.28A 5e2iA-4y4vA:
undetectable		 5e2iA-4y4vA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 TYR A 280
THR A 200
PRO A 143
ILE A 157
 None
None
None
CSO  A 176 ( 4.7A)
 0.98A 5jhdE-4y4vA:
undetectable
5jhdG-4y4vA:
undetectable		 5jhdE-4y4vA:
21.10
5jhdG-4y4vA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		3 / 3 ARG A 168
PRO A 163
ASN A 165
 None
 1.03A 5jwaA-4y4vA:
undetectable
5jwaH-4y4vA:
undetectable		 5jwaA-4y4vA:
22.58
5jwaH-4y4vA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		3 / 3 GLY A 161
ASN A 181
ARG A 168
 None
 0.74A 5w7bD-4y4vA:
undetectable		 5w7bD-4y4vA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 PHE A  61
PHE A 205
PRO A 116
PRO A 281
 GOL  A 403 ( 4.8A)
None
None
None
 1.16A 5x23A-4y4vA:
undetectable		 5x23A-4y4vA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A 324
VAL A 119
GLN A 312
PHE A 197
ILE A 199
 None
 1.38A 6becA-4y4vA:
undetectable
6becB-4y4vA:
undetectable
6becC-4y4vA:
undetectable		 6becA-4y4vA:
20.45
6becB-4y4vA:
20.45
6becC-4y4vA:
20.45