SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 8 ASP A 171
VAL A 173
HIS A 291
GLY A 169
 None
 0.93A 1ekjA-4y5fA:
undetectable
1ekjB-4y5fA:
undetectable		 1ekjA-4y5fA:
22.22
1ekjB-4y5fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 10 LEU A 121
ALA A  44
LEU A  42
LEU A  41
LEU A  85
 None
 1.19A 1gwrA-4y5fA:
undetectable		 1gwrA-4y5fA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 LEU A  69
LEU A  42
LEU A  41
ALA A  40
LEU A 103
 None
 1.14A 1ya3C-4y5fA:
undetectable		 1ya3C-4y5fA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 8 ASP A 207
TYR A 176
GLY A 184
PRO A 204
 LBV  A 401 (-3.9A)
LBV  A 401 (-4.4A)
None
None
 0.91A 2ys6A-4y5fA:
undetectable		 2ys6A-4y5fA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 PHE A 198
VAL A 159
GLN A 162
ALA A 288
LEU A 308
 LBV  A 401 ( 3.9A)
None
None
LBV  A 401 ( 4.2A)
None
 1.13A 3dh0B-4y5fA:
undetectable		 3dh0B-4y5fA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 7 GLU A 320
VAL A 316
LEU A 312
LEU A 283
 None
 0.86A 3qeoB-4y5fA:
undetectable		 3qeoB-4y5fA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 LEU A 220
TYR A 216
GLY A 285
GLY A 184
GLY A 281
 None
LBV  A 401 (-4.8A)
None
None
None
 1.16A 4blvA-4y5fA:
undetectable		 4blvA-4y5fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 9 THR A 135
LEU A 301
ALA A 139
LEU A 308
THR A 168
 None
 1.26A 4ltwA-4y5fA:
undetectable		 4ltwA-4y5fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 LEU A  69
LEU A  42
LEU A  41
ALA A  40
LEU A 103
 None
 1.12A 4ltwA-4y5fA:
undetectable		 4ltwA-4y5fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 7 LEU A 113
ALA A  44
LEU A  42
LEU A  41
 None
 0.68A 4ubsA-4y5fA:
undetectable		 4ubsA-4y5fA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 11 ALA A  58
GLY A  63
VAL A  51
LEU A 124
PHE A 126
 None
 1.16A 4zmeA-4y5fA:
undetectable		 4zmeA-4y5fA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 10 ALA A  84
VAL A 115
LEU A  42
LEU A 122
LEU A  74
 None
 1.22A 4zmeB-4y5fA:
undetectable		 4zmeB-4y5fA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 11 LEU A 121
ALA A  44
LEU A  42
LEU A  41
LEU A  85
 None
 1.24A 5hyrB-4y5fA:
undetectable		 5hyrB-4y5fA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 LEU A 103
THR A  60
LEU A  78
LEU A  74
LEU A 124
 None
 1.15A 5nfjC-4y5fA:
undetectable		 5nfjC-4y5fA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 ALA A 251
ALA A 143
ALA A 139
THR A 135
LEU A 301
 None
 1.31A 6aycA-4y5fA:
undetectable		 6aycA-4y5fA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 GLN A 262
ALA A 230
ALA A 231
VAL A 232
SER A  34
 None
 1.07A 6c2mC-4y5fA:
undetectable		 6c2mC-4y5fA:
13.03