SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		5 / 10 LEU A 601
LEU A 616
SER A 631
LEU A 634
ARG A 641
 None
 1.41A 2ceoB-4y5jA:
undetectable		 2ceoB-4y5jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		4 / 7 PHE A 701
THR A 673
LEU A 645
VAL A 663
 None
 1.07A 2cppA-4y5jA:
undetectable		 2cppA-4y5jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		5 / 12 LEU A 685
LEU A 698
ALA A 700
LEU A 653
ILE A 638
 None
 1.04A 2h42C-4y5jA:
undetectable		 2h42C-4y5jA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		5 / 11 ALA A 693
LEU A 645
ILE A 681
ILE A 635
PHE A 701
 None
 1.06A 2w9sB-4y5jA:
undetectable		 2w9sB-4y5jA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		3 / 3 PHE A 731
GLN A 798
PHE A 719
 None
 0.83A 3rv5A-4y5jA:
undetectable		 3rv5A-4y5jA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		5 / 11 ILE A 738
GLY A 774
GLU A 802
GLY A 757
ASN A 735
 None
 1.33A 4jdsC-4y5jA:
undetectable		 4jdsC-4y5jA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		4 / 8 PHE A 701
THR A 673
LEU A 645
VAL A 663
 None
 1.04A 4l4dA-4y5jA:
undetectable		 4l4dA-4y5jA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		4 / 8 PHE A 701
THR A 673
LEU A 645
VAL A 663
 None
 1.04A 4l4eA-4y5jA:
undetectable		 4l4eA-4y5jA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		4 / 8 PHE A 701
THR A 673
LEU A 645
VAL A 663
 None
 1.05A 4l4fA-4y5jA:
undetectable		 4l4fA-4y5jA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		5 / 9 ILE A 620
LEU A 616
THR A 637
ARG A 636
ILE A 638
 None
 1.30A 5ifuB-4y5jA:
undetectable		 5ifuB-4y5jA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4y5j MINI SPINDLES TOG3
(Drosophila
melanogaster) 		5 / 12 PHE A 623
LEU A 593
THR A 637
VAL A 663
SER A 621
 None
 1.33A 5v1tA-4y5jA:
undetectable		 5v1tA-4y5jA:
21.91