SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		5 / 9 LEU A 358
ARG A  39
THR A 275
VAL A 272
LEU A 287
 None
 1.36A 1fo4A-4y5rA:
undetectable		 1fo4A-4y5rA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		4 / 5 LEU A 249
GLY A 248
LYS A 265
TYR A 223
 None
None
HEC  A 402 (-3.3A)
None
 1.39A 1gtiF-4y5rA:
undetectable		 1gtiF-4y5rA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		5 / 12 PHE A  41
PRO A  37
ALA A  38
ALA A 161
ALA A  11
 None
 1.30A 2x2nA-4y5rA:
undetectable		 2x2nA-4y5rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		4 / 4 GLN A 207
PHE A 221
TYR A  72
LEU A 203
 None
 1.30A 3keeC-4y5rA:
undetectable		 3keeC-4y5rA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		4 / 5 GLN A 207
PHE A 221
TYR A  72
LEU A 203
 None
 1.41A 3sugA-4y5rA:
undetectable		 3sugA-4y5rA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		5 / 9 LEU A 358
ARG A  39
THR A 275
VAL A 272
LEU A 287
 None
 1.36A 3unaA-4y5rA:
undetectable		 3unaA-4y5rA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		5 / 9 LEU A 358
ARG A  39
THR A 275
VAL A 272
LEU A 287
 None
 1.37A 3unaB-4y5rA:
undetectable		 3unaB-4y5rA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		5 / 9 LEU A 358
ARG A  39
THR A 275
VAL A 272
LEU A 287
 None
 1.34A 3uncA-4y5rA:
undetectable		 3uncA-4y5rA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		5 / 9 LEU A 358
ARG A  39
THR A 275
VAL A 272
LEU A 287
 None
 1.35A 3uncB-4y5rA:
undetectable		 3uncB-4y5rA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		5 / 9 ALA A 326
LEU A 328
LEU A 323
ASN A 225
ILE A 226
 None
None
None
None
HEC  A 403 ( 4.5A)
 1.46A 3wdmA-4y5rA:
undetectable		 3wdmA-4y5rA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		4 / 7 VAL A 339
VAL A 343
LEU A 346
ASN A 307
 None
 0.87A 4e1gB-4y5rA:
undetectable		 4e1gB-4y5rA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		4 / 8 GLU A 355
TYR A 354
ARG A 353
GLY A  71
 None
 1.04A 4fgzA-4y5rA:
undetectable
4fgzB-4y5rA:
undetectable		 4fgzA-4y5rA:
19.83
4fgzB-4y5rA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		4 / 8 PHE A 136
ARG A 127
ALA A 123
LEU A 126
 None
 0.80A 4rkuA-4y5rA:
undetectable
4rkuJ-4y5rA:
undetectable		 4rkuA-4y5rA:
18.18
4rkuJ-4y5rA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		4 / 7 PHE A 136
ARG A 127
ALA A 123
LEU A 126
 None
 0.87A 4xk8A-4y5rA:
undetectable		 4xk8A-4y5rA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		5 / 12 ALA A  73
PHE A 185
PHE A 345
PHE A 171
THR A 219
 HEC  A 402 ( 4.6A)
None
None
None
None
 1.30A 5jlcA-4y5rA:
undetectable		 5jlcA-4y5rA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		3 / 3 THR A 275
THR A  42
ARG A  39
 None
 0.94A 5wm2A-4y5rA:
undetectable		 5wm2A-4y5rA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG
(Paracoccus
denitrificans) 		4 / 4 THR A 275
THR A  42
ALA A  40
ARG A  39
 None
 1.00A 5wm7A-4y5rA:
undetectable		 5wm7A-4y5rA:
22.40