SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Staphylococcus
aureus;
Sesbania
mosaic
virus) 		4 / 7 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.83A 1gtnC-4y5zA:
undetectable
1gtnD-4y5zA:
undetectable		 1gtnC-4y5zA:
11.62
1gtnD-4y5zA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Staphylococcus
aureus;
Sesbania
mosaic
virus) 		4 / 6 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.84A 1gtnD-4y5zA:
undetectable
1gtnE-4y5zA:
undetectable		 1gtnD-4y5zA:
11.62
1gtnE-4y5zA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Staphylococcus
aureus;
Sesbania
mosaic
virus) 		4 / 7 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.87A 1gtnF-4y5zA:
undetectable
1gtnG-4y5zA:
undetectable		 1gtnF-4y5zA:
11.62
1gtnG-4y5zA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Staphylococcus
aureus;
Sesbania
mosaic
virus) 		4 / 7 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.86A 1gtnJ-4y5zA:
undetectable
1gtnK-4y5zA:
undetectable		 1gtnJ-4y5zA:
11.62
1gtnK-4y5zA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		5 / 12 VAL A 155
LEU A 158
SER A 159
GLY A 167
SER A 138
 None
 1.05A 1pxxC-4y5zA:
undetectable		 1pxxC-4y5zA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		3 / 3 TRP A 107
GLU A  81
TYR A 254
 None
 1.09A 2a3aA-4y5zA:
undetectable		 2a3aA-4y5zA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		5 / 10 VAL A 169
GLY A  87
ALA A 247
ALA A 246
THR A 135
 None
 1.19A 3ucjA-4y5zA:
undetectable		 3ucjA-4y5zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		5 / 10 VAL A 169
GLY A  87
ALA A 247
ALA A 246
THR A 135
 None
 1.18A 3ucjB-4y5zA:
undetectable		 3ucjB-4y5zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		5 / 12 VAL A 155
LEU A 158
SER A 159
GLY A 167
SER A 138
 None
 1.00A 4coxC-4y5zA:
undetectable		 4coxC-4y5zA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		5 / 10 LEU A  98
GLU A  97
SER A  96
THR A 150
ASP A 149
 None
 1.46A 4driB-4y5zA:
undetectable		 4driB-4y5zA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		4 / 6 ASP A 196
ARG A 162
GLY A 142
VAL A 165
 None
 1.03A 4oltA-4y5zA:
undetectable		 4oltA-4y5zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		4 / 6 ASP A 196
ARG A 162
GLY A 142
VAL A 165
 None
 0.98A 4oltB-4y5zA:
undetectable		 4oltB-4y5zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		5 / 12 VAL A 155
LEU A 158
SER A 159
GLY A 167
SER A 138
 None
 1.09A 4otyA-4y5zA:
undetectable		 4otyA-4y5zA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Staphylococcus
aureus;
Sesbania
mosaic
virus) 		3 / 3 VAL A 197
SER A 122
TRP A 120
 None
 1.04A 5jwaA-4y5zA:
undetectable		 5jwaA-4y5zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		4 / 8 GLU A  97
VAL A  99
LEU A 108
THR A 106
 None
 1.02A 5sxqB-4y5zA:
undetectable		 5sxqB-4y5zA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN
(Sesbania
mosaic
virus;
Staphylococcus
aureus) 		4 / 8 GLU A  97
VAL A  99
LEU A 108
THR A 106
 None
 1.00A 5syjA-4y5zA:
undetectable		 5syjA-4y5zA:
17.27