SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4y61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 8 VAL A 122
ARG A  75
ALA A  48
GLU A 100
 None
 1.08A 1dmiA-4y61A:
undetectable
1dmiB-4y61A:
undetectable		 1dmiA-4y61A:
22.43
1dmiB-4y61A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		5 / 12 LEU B 165
ALA B 141
LEU B 125
ASN B 168
LEU B  98
 None
 1.04A 1og5A-4y61B:
undetectable		 1og5A-4y61B:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 7 PHE A 245
ALA A 320
ILE A 262
PRO A 249
 None
 0.98A 1oniA-4y61A:
undetectable
1oniB-4y61A:
undetectable		 1oniA-4y61A:
18.13
1oniB-4y61A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 6 PHE A 245
ALA A 320
ILE A 262
PRO A 249
 None
 1.09A 1oniH-4y61A:
undetectable
1oniI-4y61A:
undetectable		 1oniH-4y61A:
18.13
1oniI-4y61A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		5 / 11 TYR B 138
ILE B 164
VAL B 162
ILE B 208
MET B 209
 None
 0.97A 1uduA-4y61B:
undetectable		 1uduA-4y61B:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		5 / 12 ARG A  90
LEU A 120
PHE A  50
ALA A  48
VAL A  47
 None
 0.94A 2oc8A-4y61A:
undetectable		 2oc8A-4y61A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 7 GLN A  40
ARG A  75
LEU A 120
ASP A  99
 None
 1.05A 2qqcB-4y61A:
undetectable
2qqcC-4y61A:
undetectable		 2qqcB-4y61A:
15.31
2qqcC-4y61A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 7 LEU A 120
ASP A  99
GLN A  40
ARG A  75
 None
 1.05A 2qqcA-4y61A:
undetectable
2qqcF-4y61A:
undetectable		 2qqcA-4y61A:
8.83
2qqcF-4y61A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 7 LEU A 120
ASP A  99
GLN A  40
ARG A  75
 None
 0.99A 2qqcG-4y61A:
undetectable
2qqcJ-4y61A:
undetectable		 2qqcG-4y61A:
8.83
2qqcJ-4y61A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 7 LEU A 120
ASP A  99
GLN A  40
ARG A  75
 None
 1.03A 2qqcI-4y61A:
undetectable
2qqcL-4y61A:
undetectable		 2qqcI-4y61A:
8.83
2qqcL-4y61A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		4 / 8 LEU B  77
LYS B 121
ASN B 120
LEU B 117
 None
 1.18A 2xn3A-4y61B:
undetectable
2xn3B-4y61B:
undetectable		 2xn3A-4y61B:
23.77
2xn3B-4y61B:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		4 / 7 VAL B  89
ASN A 229
GLY A 210
ASP A 208
 None
 0.85A 2y05A-4y61B:
undetectable
2y05B-4y61B:
undetectable		 2y05A-4y61B:
21.81
2y05B-4y61B:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		4 / 5 PHE B 106
ALA B 105
THR B 129
LEU B  98
 None
 1.20A 3t3zC-4y61B:
undetectable		 3t3zC-4y61B:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		4 / 4 LEU B 131
GLY B 132
LEU B 133
GLU B 134
 None
 1.10A 3tgvB-4y61B:
undetectable		 3tgvB-4y61B:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		5 / 12 TRP B 230
LEU B 227
ILE B 211
GLN B 212
ILE B 241
 None
 1.45A 4a79A-4y61B:
undetectable		 4a79A-4y61B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		5 / 12 LEU B 165
LEU B 170
ASN B 191
LEU B 171
MET B 196
 None
 1.23A 4fn9B-4y61B:
undetectable		 4fn9B-4y61B:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		3 / 3 SER A 359
ALA A 402
VAL A 401
 None
 0.58A 4o2bA-4y61A:
undetectable		 4o2bA-4y61A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		3 / 3 SER B  86
ALA B  88
VAL B  89
 None
 0.62A 4o2bA-4y61B:
undetectable		 4o2bA-4y61B:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		5 / 12 LEU B 139
LEU B  91
LEU B 117
ASN B  96
ILE B 101
 None
 1.10A 4o2bB-4y61B:
undetectable		 4o2bB-4y61B:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		3 / 3 SER A 359
ALA A 402
VAL A 401
 None
 0.51A 4x1iA-4y61A:
undetectable		 4x1iA-4y61A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		3 / 3 SER B  86
ALA B  88
VAL B  89
 None
 0.60A 4x1iA-4y61B:
undetectable		 4x1iA-4y61B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		3 / 3 SER A 359
ALA A 402
VAL A 401
 None
 0.52A 5eypA-4y61A:
undetectable		 5eypA-4y61A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		3 / 3 SER B  86
ALA B  88
VAL B  89
 None
 0.56A 5eypA-4y61B:
undetectable		 5eypA-4y61B:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		4 / 8 ASN B 144
PHE B 130
HIS B  92
THR B  75
 None
 1.37A 5hqaA-4y61B:
undetectable		 5hqaA-4y61B:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		5 / 12 LEU B 165
ILE B 146
LEU B 139
ASN B 118
LEU B 117
 None
 1.10A 5nfjB-4y61B:
undetectable		 5nfjB-4y61B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4y61 SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus) 		5 / 12 LEU B 165
ILE B 146
LEU B 139
ASN B 118
LEU B 117
 None
 1.09A 5nfjC-4y61B:
undetectable		 5nfjC-4y61B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
SLIT AND NTRK-LIKE
PROTEIN 2
(Mus
musculus;
Mus
musculus) 		3 / 3 GLY A 138
VAL B 236
MET B 209
 None
 0.63A 5ycpA-4y61A:
undetectable		 5ycpA-4y61A:
11.83